Methamphetamine abuse, HIV infection, and neurotoxicity.
Methamphetamine abuse, HIV infection, and neurotoxicity.
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发表时间：
2009-09
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通讯作者：
Benjamin C. Reiner;James P. Keblesh;H. Xiong
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作者：
Benjamin C. Reiner;James P. Keblesh;H. Xiong
甲基苯丙胺（Methe）的使用和人类免疫缺陷病毒（HIV）感染是当今世界的主要公共卫生问题。大量证据表明，使用甲基苯丙胺会大大增加艾滋病毒转染的风险。研究表明，艾滋病毒感染和甲基苯丙胺滥用都可能导致神经元损伤，导致神经退行性变。虽然许多研究都集中在甲基和艾滋病毒对大脑的单独影响，但很少有研究对它们在神经系统中的共同作用进行调查。本文综述了近年来甲基苯丙胺和艾滋病病毒对神经退行性变的个体效应及其潜在机制的研究进展，并探讨了它们对大脑的共病效应。
Methamphetamine (Meth) use and human immunodeficiency virus (HIV) infection are major public health problems in the world today. Ample evidence indicates that HIV transfection risk is greatly enhanced with Meth use. Studies have shown that both HIV infection and Meth abuse can cause neuronal injury leading to neurodegeneration. While many studies have focused on the individual effects of Meth and HIV on the brain, few investigations have been carried out on their co-morbid effect in the nervous system. In this review, we try to summarize recent progress on individual effects of Meth and HIV on neurodegeneration and their potential underlying mechanisms, in addition to exploring their co-morbid effect on the brain.