Nickel(ii)-catalyzed asymmetric thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles
Nickel(ii)-catalyzed asymmetric thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles
复制标题
镍(ii)催化α-重氮吡唑酰胺与硫代吲哚的不对称硫代克莱森重排
DOI：
10.1039/d0cc04590j
复制
发表时间：
2020
影响因子：
4.9
通讯作者：
Xiaoming Feng
中科院分区：
文献类型：
--
作者：
Wei Yang;Xiaobin Lin;Yongyan Zhang;Weidi Cao;Xiaohua Liu;Xiaoming Feng
采用修饰的手性N，N′-二氧化物配体实现了镍催化的α-重氮吡唑酰胺与硫代吲哚的硫代Claisen重排反应，在温和的反应条件下高产率（高达95%）和良好的对映选择性（高达96%ee）得到了一系列C3取代吲哚衍生物.根据前人的报道和催化剂的X-射线晶体结构，提出了一个可能的过渡态模型。
A nickel(II) catalyzed enantioselective thio-Claisen rearrangement of α-diazo pyrazoleamides with thioindoles was realized with modified chiral N,N′-dioxide ligands, affording a variety of C3-substituted indole derivatives in high yields (up to 95%) with excellent enantioselectivities (up to 96% ee) under mild reaction conditions. A possible transition state model was proposed based on previous reports and the X-ray crystal structure of the catalyst.