Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress.
Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress.
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DOI：
10.1016/j.molcel.2010.09.026
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发表时间：
2010-10-22
期刊：
影响因子：
16
通讯作者：
Sabatini DM
中科院分区：
文献类型：
--
作者：
Sengupta S;Peterson TR;Sabatini DM
大丝氨酸/苏氨酸蛋白激酶mTOR通过协调合成代谢和分解代谢过程与营养、能量和氧可用性以及生长因子信号传导来调节细胞和生物体内平衡。细胞和生物体经历了各种各样的损伤，这些损伤扰乱了由mTOR控制的稳态系统，因此需要适当的应激反应来允许细胞继续发挥功能。应激可以表现为上游信号的过量或缺乏，或者由于途径上游效应子的遗传扰动。mTOR使两个大的蛋白质复合物成核，这两个蛋白质复合物是帮助缓冲细胞免受应激的途径中的重要节点，并且与应激相关的表型和疾病（如衰老、肿瘤发生和糖尿病）的进展有关。本文综述了mTOR复合物1通路的关键组成部分以及各种压力如何影响它们。
The large serine/threonine protein kinase mTOR regulates cellular and organismal homeostasis by coordinating anabolic and catabolic processes with nutrient, energy, and oxygen availability and growth factor signaling. Cells and organisms experience a wide variety of insults that perturb the homeostatic systems governed by mTOR, and therefore require appropriate stress responses to allow cells to continue to function. Stress can manifest from an excess or lack of upstream signals, or due to genetic perturbations in upstream effectors of the pathway. mTOR nucleates two large protein complexes that are important nodes in the pathways that help buffer cells from stresses, and are implicated in the progression of stress-associated phenotypes and diseases, such as aging, tumorigenesis, and diabetes. This review focuses on the key components of the mTOR Complex 1 pathway and on how various stresses impinge upon them.
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