Control of an H1N1 outbreak in a correctional facility in central Taiwan
Control of an H1N1 outbreak in a correctional facility in central Taiwan
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DOI：
10.1016/j.jmii.2015.05.005
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发表时间：
2017-04-01
影响因子：
7.4
通讯作者：
Wu, Chieh-Liang
中科院分区：
文献类型：
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作者：
Chao, Wen-Cheng;Liu, Po-Yu;Wu, Chieh-Liang
背景资料：由于囚犯之间不可避免的密切和长期接触，控制H1N1在惩教设施中的爆发是困难的。目前的研究报告在一个惩教设施的H1N1疫情，并调查奥司他韦的有效性，以控制H1N1的传播。方法：所有2690名囚犯在监狱接受医疗服务，从一个单一的医院。根据爆发期间出现呼吸道症状的医学诊断，编制了诊断为流感的患者名单。结果：在4周的疫情期间，24.6%（663/2690）的犯人出现流感相关症状，50.5%（335/663）符合流感样疾病（ILI）伴发热的标准，ILI的总发病率为12.8%。12名囚犯因复杂的流感入院，其中3人呼吸衰竭。在第二周结束时提供了奥司他韦，并分析了奥司他韦在监狱七个主要部分的1004名囚犯中的有效性。在奥司他韦干预后，ILI发病率从第1和第2周之间的12.6 +/- 4.1%降至第3和第4周之间的4.8 +/- 2.4%（p = 0.018）。在878名未感染的服刑人员中，47.0%（413/878）的服刑人员在第2周末接受了预防性奥司他韦治疗，ILI的发生率低于未接受预防性奥司他韦治疗的服刑人员（6.2%vs2.4%，p = 0.013）。使用奥司他韦可能是一种实际的干预措施，以控制H1N1疫情在这样的封闭环境。(C)2015年，台湾微生物学会。出版社：Elsevier Taiwan LLC
Background: Controlling the outbreak of H1N1 in correctional facilities is difficult due to the inevitable close and prolonged contact between inmates. The current study reports an H1N1 outbreak in a correction facility and investigates the effectiveness of oseltamivir to control the spread of H1N1.Methods: All 2690 inmates at the prison received medical service from a single hospital. A list of patients with a diagnosis of influenza was compiled based on medical diagnoses with respiratory symptoms during the outbreak period. The outbreak was then investigated using both chart review and questionnaires.Results: In the 4-week outbreak period, 24.6% (663/2690) of inmates experienced influenza-associated symptoms, 50.5% (335/663) fulfilled the criteria for influenza-like illness (ILI) with fever, and the overall attack rate of ILI was 12.8%. Twelve inmates were admitted for complicated influenza, and three of them experienced respiratory failure. Oseltamivir was provided at the end of the 2nd week, and the effectiveness of oseltamivir in the 1004 inmates from seven major sections in the prison was analyzed. The ILI incidence rate reduced from 12.6 +/- 4.1% between the 1st and 2nd weeks to 4.8 +/- 2.4% between the 3rd and 4th weeks (p = 0.018) after the oseltamivir intervention. In the 878 uninfected inmates 47.0% (413/878) of inmates received prophylactic oseltamivir at the end of the 2nd week, the incidence of ILI was lower than those without prophylaxis (6.2% versus 2.4%; p = 0.013).Conclusion: H1N1 influenza spread rapidly in the correctional facility. The use of oseltamivir may be a practical intervention to control an H1N1 outbreak an enclosed environment such as this. (C) 2015, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.