New measurements for hadrontherapy and space radiation: biology.
New measurements for hadrontherapy and space radiation: biology.
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发表时间：
2001
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通讯作者：
E. Blakely
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作者：
E. Blakely
优化强子疗法的临床疗效和确定空间研究的辐射风险估计的双重目标已经交叉成为研究带电粒子生物效应的共同重点。本文简要介绍了最近国际上在粒子束（主要是质子、碳和铁离子）效应的生物学和临床研究方面的加速器设施的进展。分子、细胞和组织对一定电离密度辐射反应的基本机制仍在研究中。正常组织的后期效应，特别是癌症的风险，对这两个研究领域都很重要。最近的出版物证明，国际合作加快了进展速度。与关键器官（特别是中枢神经系统）的生物放射毒性、个体对辐射致癌的放射敏感性以及混合辐射场的影响分析有关的生物医学研究的特定领域仍需要更多的研究。提出了解决这些问题的建议。
The dual goals of optimizing clinical efficacy of hadrontherapy and determining radiation risk estimates for space research have intersected to a common focus for investigation of the biological effects of charged particles. This paper briefly highlights recent international progress at accelerator facilities engaged in both biological and clinical studies of the effects of particle beams, primarily protons, carbon and iron ions. Basic mechanisms of molecular, cellular and tissue responses continue under investigation for radiations with a range of ionization densities. Late normal tissue effects, including the risk of cancer in particular, are of importance for both research fields. International cooperation has enhanced the rate of progress as evidenced by recent publications. Specific areas of biomedical research related to the biological radiotoxicity of critical organs (especially the central nervous system), individual radiosensitivities to radiation carcinogenesis, and the analysis of effects in mixed radiation fields still require more research. Recommendations for addressing these issues are made.