MECHANISM OF CARBANION ADDITION TO CARBONYL-COMPOUNDS - EQUILIBRIA AND KINETICS OF SUBSTITUTED CYANOHYDRIN CLEAVAGE AND FORMATION IN AQUEOUS-SOLUTION - SUBSTITUTED CYANOHYDRIN PROTON DISSOCIATION-CONSTANTS
MECHANISM OF CARBANION ADDITION TO CARBONYL-COMPOUNDS - EQUILIBRIA AND KINETICS OF SUBSTITUTED CYANOHYDRIN CLEAVAGE AND FORMATION IN AQUEOUS-SOLUTION - SUBSTITUTED CYANOHYDRIN PROTON DISSOCIATION-CONSTANTS
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DOI：
10.1021/ja00487a025
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发表时间：
1978-01-01
影响因子：
15
通讯作者：
KALLEN, RG
中科院分区：
文献类型：
--
作者：
CHING, WM;KALLEN, RG
研究了稀水溶液中氰醇的生成和裂解反应。氰醇的分解可能为丝氨酸羟甲基酶(EC 2.1.2.1)提供了一个模型系统。报道了取代基对氰醇生成平衡和动力学的影响，包括取代氰醇的质子解离常数。这些数据使人们能够对酶反应和非酶反应的机理进行比较和得出结论。
The reactions of cyanohydrin formation and cleavage in dilute aqueous solutions were studied. Cyanohydrin breakdown may provide a model system for serine hydroxymethylase (EC 2.1.2.1). Substituent effects upon the equilibria and kinetics of cyanohydrin formation, including proton dissociation constants for substituted cyanohydrins are reported. The data enable comparisons and conclusions to be made regarding the mechanism of both enzymatic and nonenzymatic reactions.