Disease characteristics and psychosocial factors: Explaining the expression of quality of life in childhood epilepsy
Disease characteristics and psychosocial factors: Explaining the expression of quality of life in childhood epilepsy
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DOI：
10.1016/j.yebeh.2010.02.023
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发表时间：
2010-05-01
影响因子：
2.6
通讯作者：
Rosenbaum, Peter L.
中科院分区：
文献类型：
--
作者：
Ronen, Gabriel M.;Streiner, David L.;Rosenbaum, Peter L.
目的：探讨、识别和了解生物医学和心理社会因素对使用CHEQOL-25评估儿童和青少年癫痫患者健康相关生活质量(HRQL)的贡献。方法：识别和测量可能影响HRQL的变量；将变量分为四个概念类别；使用简单和分层线性回归建立CHEQOL-25作为变量分组的函数模型。研究对象为8-15岁癫痫患者及其家长。总体而言，与生物医学和心理社会变量相关的独特变量分别为R-2=0.22和0.29，对于儿童自我报告的HRQL和R-2=0.11和0.13，对于父母-代理报告。结论：本研究增加了我们对该人群中影响HRQL表达的因素的理解。由于样本量有限且变量数量较多，对这些结果的解释应谨慎。(C)2010 Elsevier Inc.保留所有权利。
Objectives: To explore, identify and understand the contribution that biomedical and psychosocial factors make to the assessment of health-related quality of life (HRQL) of children and youth with epilepsy using the CHEQOL-25.Methods: We identified and measured variables that may influence HRQL; grouped the variables into four conceptual categories; and used simple and hierarchical linear regressions to model CHEQOL-25 as a function of these variable groupings. Participants were 8-15 year olds with epilepsy and their parents.Results: 131 child and parent pairs participated. Overall, the unique variances associated with the biomedical and psychosocial variables are R-2=0.22 and 0.29, respectively, for child self-reported HRQL and R-2=0.11 and 0.13, respectively, for parent-proxy report.Conclusions: This study increases our understanding of factors that contribute to the expression of HRQL in this population. These results should be interpreted with caution due to the limited sample size and large number of variables. (C) 2010 Elsevier Inc. All rights reserved.