Apoptosis of skeletal muscle cells and the pathogenesis of myositis: a perspective.
Apoptosis of skeletal muscle cells and the pathogenesis of myositis: a perspective.
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DOI：
10.1007/s11926-001-0037-y
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发表时间：
2001-08-01
影响因子：
5
通讯作者：
Ahearn, J M
中科院分区：
文献类型：
--
作者：
Liu, C C;Ahearn, J M
细胞凋亡是一种遗传控制的细胞死亡形式，发生在许多生物学过程中，包括胚胎发生、免疫细胞发育和外周免疫耐受的维持。最近的研究表明，实质细胞的凋亡可能在提供自身抗原以启动自身免疫反应中发挥作用。骨骼肌细胞完全分化，多核。细胞凋亡在发育中的成肌细胞中有描述，最近在成熟的肌管中有描述。然而，细胞凋亡在骨骼肌病理中的参与尚不清楚。本文综述了有关骨骼肌细胞凋亡的发生在选定的肌肉疾病的可用数据。它还讨论了肌细胞凋亡在自身免疫性疾病如特发性炎性肌病的发展中的潜在作用。
Apoptosis is a genetically controlled form of cell death that occurs in many biologic processes including embryogenesis, immune cell development, and maintenance of peripheral immune tolerance. Recent studies have yielded evidence suggesting that apoptosis of parenchymal cells may play a role in providing self-antigens to initiate autoimmune reactions. Skeletal muscle cells are fully differentiated and multinucleated. Apoptosis has been described in developing myoblasts and, recently, in mature myotubes. However, the involvement of apoptosis in skeletal muscle pathologies is unclear. This article reviews the available data concerning the occurrence of skeletal muscle cell apoptosis in selected muscle diseases. It also discusses the potential role of muscle cell apoptosis in the development of autoimmune diseases such as idiopathic inflammatory myopathies.