Pnictogen Semimetal (Sb, Bi)-Based Nanomaterials for Cancer Imaging and Therapy: A Materials Perspective
Pnictogen Semimetal (Sb, Bi)-Based Nanomaterials for Cancer Imaging and Therapy: A Materials Perspective
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用于癌症成像和治疗的 Pnictogen 半金属（Sb，Bi）基纳米材料：材料视角
DOI：
10.1021/acsnano.0c07899
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发表时间：
2021
期刊：
影响因子：
17.1
通讯作者：
Li wanwan
中科院分区：
文献类型：
--
作者：
Yu Xujiang;Liu Xinyi;Yang Kai;Chen Xiaoyuan;Li wanwan
创新的多功能纳米材料通过促进同步癌症成像和治疗而引起了当前研究的极大兴趣。其中，锑（Sb）和铋（Bi）基纳米粒子是具有增强癌症治疗诊断功效的多功能的重要物种。尽管发展迅速，但先前的大量工作将锑基和铋基纳米粒子视为相互独立的物种，因此缺乏对它们在癌症治疗诊断学中的关系的透彻理解。我们在此提出，Sb 和 Bi 的相同化学性质（均为半金属）为它们衍生的纳米粒子提供了固有的多功能，用于近红外激光驱动和/或基于 X 射线的癌症成像和治疗，以及一些其他赋予的功能。概述了用于癌症治疗诊断的锑基和铋基纳米粒子的最新进展，以强调化学性质和多功能之间的关系。以这种方式对锑基和铋基纳米粒子的理解可能有助于进一步设计用于癌症治疗诊断的智能多功能纳米粒子。
Innovative multifunctional nanomaterials have attracted tremendous interest in current research by facilitating simultaneous cancer imaging and therapy. Among them, antimony (Sb)- and bismuth (Bi)-based nanoparticles are important species with multifunction to boost cancer theranostic efficacy. Despite the rapid development, the extensive previous work treated Sb- and Bi-based nanoparticles as mutually independent species, and therefore a thorough understanding of their relationship in cancer theranostics was lacking. We propose here that the identical chemical nature of Sb and Bi, being semimetals, provides their derived nanoparticles with inherent multifunction for near-infrared laser-driven and/or X-ray-based cancer imaging and therapy as well as some other imparted functions. An overview of recent progress on Sb- and Bi-based nanoparticles for cancer theranostics is provided to highlight the relationship between chemical nature and multifunction. The understanding of Sb- and Bi-based nanoparticles in this way might shed light on the further design of smart multifunctional nanoparticles for cancer theranostics.