STEREOTYPED RESPONDING BY SCHIZOPHRENIC-PATIENTS ON A 2-CHOICE GUESSING TASK
STEREOTYPED RESPONDING BY SCHIZOPHRENIC-PATIENTS ON A 2-CHOICE GUESSING TASK
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DOI：
10.1017/s0033291700051485
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发表时间：
1983-01-01
影响因子：
6.9
通讯作者：
DONE, DJ
中科院分区：
文献类型：
--
作者：
FRITH, CD;DONE, DJ
在一系列试验中的每一项中，受试者都必须猜测一个十字是出现在电脑屏幕的左侧还是右侧。交叉位置的顺序是随机的。正常对照组、躁郁症患者和老年痴呆症患者产生的反应序列相对随机，有阳性症状的急性精神分裂症患者也是如此。有阴性症状的急性精神分裂症患者和慢性精神分裂症患者产生更多的刻板印象序列和多反应交替(LRLR)。具有阴性症状和智力退化(缺陷状态)的慢性精神分裂症患者产生带有许多保留的非常刻板印象的序列(LLLL)。这种对反应序列的严格限制类似于动物在安非他明治疗后表现出的情况。据认为，这是由于较高级别的控制过程受损，当事实证明这些行为序列不合适时，该过程通常会抑制行为序列的重复。
On each of a sequence of trials subjects had to guess whether a cross would appear on the left or the right side of a computer screen. The sequence of cross positions was random. Normal controls, manic-depressive patients and patients with senile dementia produced relatively random sequences of responses, as did acute schizophrenic patients with positive symptoms. Acute schizophrenic patients with negative symptoms and chronic patients produced more stereotyped sequences with many response alternations (LRLR). Chronic schizophrenic patients with negative symptoms and intellectual deterioration (defect state) produced very stereotyped sequences with many preservations (LLLL). This severe restriction of response sequences is similar to that shown by animals after treatment with amphetamine. It is suggested that it is due to an impairment of a higher order control process which normally inhibits the repetition of sequences of behaviour when these have proved inappropriate.