Nanocrystal targeting in vivo
Nanocrystal targeting in vivo
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DOI：
10.1073/pnas.152463399
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发表时间：
2002-10-01
影响因子：
11.1
通讯作者：
Ruoslahti, E
中科院分区：
文献类型：
--
作者：
Åkerman, ME;Chan, WCW;Ruoslahti, E
无机纳米结构与生物系统的接口最近引起了生物学和医学的广泛兴趣。纳米颗粒被认为具有作为新型血管内探针用于诊断（例如，成像）和治疗目的（例如，药物递送）。成功的纳米颗粒递送的关键问题包括靶向特定组织和细胞类型的能力，以及从被称为网状内皮系统的生物颗粒过滤器中逃逸的能力。我们着手探索使用半导体量子点（qdots）体内靶向的可行性。Qdots是小的（
Inorganic nanostructures that interface with biological systems have recently attracted widespread interest in biology and medicine. Nanoparticles are thought to have potential as novel intravascular probes for both diagnostic (e.g., imaging) and therapeutic purposes (e.g., drug delivery). Critical issues for successful nanoparticle delivery include the ability to target specific tissues and cell types and escape from the biological particulate filter known as the reticuloendothelial system. We set out to explore the feasibility of in vivo targeting by using semiconductor quantum dots (qdots). Qdots are small (