Updates on the research and development of absorbable metals for biomedical applications.
Updates on the research and development of absorbable metals for biomedical applications.
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用于生物医学应用的可吸收金属的研究和开发的最新动态。
DOI：
10.1007/s40204-018-0091-4
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发表时间：
2018-06
影响因子：
4.9
通讯作者：
Hermawan H
中科院分区：
文献类型：
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作者：
Hermawan H
可吸收金属是在生理环境中腐蚀的金属，构成了一类用于临时医疗植入应用的新型生物材料。这些金属的引入将金属植入物的既定范例从防止腐蚀转变为直接应用。过去十年，人们对可吸收金属的兴趣一直在增长。科学出版物的迅速增加、标准的逐步发展以及首批商业产品的推出都证明了这一点。铁、镁、锌及其合金是目前三种可吸收金属族。镁基金属是最进步的金属家族，拥有从基础研究和转化研究中获得的大量数据。尽管为克服铁基金属的弱点付出了巨大努力，但铁基金属仍然面临着低体内腐蚀率的重大挑战。锌基金属是新型可吸收金属替代品，其腐蚀速率适中，介于铁和镁之间。本文简要回顾了可吸收金属研究和开发的最新进展、最重要的发现、剩余的挑战以及对未来方向的展望。
Absorbable metals, metals that corrode in physiological environment, constitute a new class of biomaterials intended for temporary medical implant applications. The introduction of these metals has shifted the established paradigm of metal implants from preventing corrosion to its direct application. Interest toward absorbable metals has been growing in the past decade. This is proved by the rapid increase in scientific publication, progressive development of standards, and launching the first commercial products. Iron, magnesium, zinc, and their alloys are the current three absorbable metals families. Magnesium-based metals are the most progressing family with a large data set obtained from both basic and translational research. Iron-based metals are still facing a major challenge of low in vivo corrosion rate despite the significant efforts that have been put to overcome its weakness. Zinc-based metals are the new alternative absorbable metals with moderate corrosion rates that fall between those of iron and magnesium. This manuscript provides a brief review on the latest progress in the research and development of absorbable metals, the most important findings, the remaining challenges, and the perspective on the future direction.