Abnormal corpus callosum myelination in pediatric bipolar patients
Abnormal corpus callosum myelination in pediatric bipolar patients
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DOI：
10.1016/j.jad.2007.10.006
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发表时间：
2008-06-01
影响因子：
6.6
通讯作者：
Soares, Jair C.
中科院分区：
文献类型：
--
作者：
Caetano, Sheila C.;Silveira, Camila Magalhaes;Soares, Jair C.
背景：据报道，在成年双相情感障碍患者中，痂体内信号强度降低被认为是髓鞘形成异常的一个指标。方法：对双相情感障碍儿童青少年(n=16，平均年龄+/-S.D.=15.5+/-3.4岁)和匹配的健康对照组(n=21，平均年龄+/-S.D.=16.9±3.8岁)进行1.5T MRI脑扫描。使用运行NIH Image 1.62软件的Apple Power Mac G4测量胼胝体信号强度。结果：与健康受试者(ANCOVA，均为P<；0.05，年龄和性别为协变量)相比，双相儿童和青少年的所有胼胝体亚区(膝部、前部、后部、峡部和压部)的胼胝体信号强度均显著降低。局限性：样本量相对较小。结论：在儿童和青少年双相情感障碍的病理生理学中，可能是由于神经发育过程中髓鞘的改变，导致了胼胝体的异常。(C)2007爱思唯尔B.V保留所有权利。
Background: Decreased signal intensity in the corpus callosum, reported in adult bipolar disorder patients, has been regarded as an indicator of abnormalities in myelination. Here we compared the callosal signal intensity of children and adolescents with bipolar disorder to that of matched healthy subjects, to investigate the hypothesis that callosal myelination is abnormal in pediatric bipolar patients.Methods: Children and adolescents with DSM-lV bipolar disorder (n=16, mean age +/- S.D. = 15.5 +/- 3.4 y) and matched healthy comparison subjects (n=21, mean age +/- S.D.=16.9 3.8 y) underwent a 1.5 T MRI brain scan. Corpus callosuin signal intensity was measured using an Apple Power Mac G4 running NIH Image 1.62 software.Results: Bipolar children and adolescents had significantly lower corpus callosum signal intensity for all callosal sub-regions (genu, anterior body, posterior body, isthmus and splenium) compared to healthy subjects (ANCOVA, all p < 0.05, age and gender as covariates). Limitations: Relatively small sample size.Conclusions: Abnormalities in corpus callosum, probably due to altered myelination during neurodevelopment, may play a role in the pathophysiology of bipolar disorder among children and adolescents. (c) 2007 Elsevier B.V All rights reserved.