Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast
Photoacoustic imaging of human lymph nodes with endogenous lipid and hemoglobin contrast
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DOI：
10.1117/1.jbo.20.5.050504
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发表时间：
2015-05-01
影响因子：
3.5
通讯作者：
Beard, Paul C.
中科院分区：
文献类型：
--
作者：
Guggenheim, James A.;Allen, Thomas J.;Beard, Paul C.
淋巴结在转移性癌症扩散中起核心作用，并且是关键的临床评估目标。异常淋巴结血管化、形态和大小可能表明存在疾病，但使用现有的临床成像方式可能难以足够准确地可视化。为了探索光声成像用于评估淋巴结的潜在效用，使用高分辨率三维光声扫描仪在多个波长下获得离体样品的图像。这些图像显示，基于血红蛋白的对比显示了淋巴结血管系统，基于脂质的对比显示了外部淋巴结的大小、形状和边界完整性。这两种互补对比度的来源可能允许间接观察癌症，表明光声成像作为淋巴结临床评估工具的未来作用。(C)2015年，美国光电仪器工程师学会（SPIE）
Lymph nodes play a central role in metastatic cancer spread and are a key clinical assessment target. Abnormal node vascularization, morphology, and size may be indicative of disease but can be difficult to visualize with sufficient accuracy using existing clinical imaging modalities. To explore the potential utility of photoacoustic imaging for the assessment of lymph nodes, images of ex vivo samples were obtained at multiple wavelengths using a high-resolution three-dimensional photoacoustic scanner. These images showed that hemoglobin based contrast reveals nodal vasculature and lipid-based contrast reveals the exterior node size, shape, and boundary integrity. These two sources of complementary contrast may allow indirect observation of cancer, suggesting a future role for photoacoustic imaging as a tool for the clinical assessment of lymph nodes. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)