REINFORCEMENT WITH INTRA-GASTRIC INFUSIONS OF ETHANOL - BLOCKING EFFECT OF FLA-57
REINFORCEMENT WITH INTRA-GASTRIC INFUSIONS OF ETHANOL - BLOCKING EFFECT OF FLA-57
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DOI：
10.1016/0091-3057(79)90038-8
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发表时间：
1979-01-01
影响因子：
3.6
通讯作者：
SMITH, SG
中科院分区：
文献类型：
--
作者：
DAVIS, WM;WERNER, TE;SMITH, SG
据报道，弗拉57 [4-甲基-1-高哌嗪二硫代羧酸]对大鼠口服乙醇摄入的抑制作用归因于多巴胺β-受体阻滞剂的抑制。羟化酶弗拉57（50 mg/kg，i.p.）抑制乙醇剂量（25 mg/kg）胃内（IG）给药的压杆。对乙醇口服摄入量的影响可能不归因于味觉因素，例如，降低了乙醇溶液的适口性。相同剂量的弗拉57不抑制IG剂量的甜牛奶的反应。一般来说，通过一些非特异性的抑制或毒性作用，没有食欲行为受损。乙醇的主要强化作用，当用于通过重复配对建立蜂鸣器作为条件反射器时，如果在配对前给予弗拉57，则被阻断。这通过在后来的条件强化测试中这些大鼠未能高于基线水平的压杆来证明，这与在乙醇之前接受盐水而不是弗拉57的大鼠所观察到的增加的响应形成对比。先前关于口服乙醇的发现得到支持，并且证实了弗拉57可以损害乙醇在大鼠中产生正强化的机制。
Suppression of oral intake of ethanol by FLA 57 [4-methy-l-homopiperazinedithiocarboxylic acid] was reported for rats and was attributed to an inhibition of dopamine .beta.-hydroxylase. The ability of FLA 57 (50 mg/kg, i.p.) to suppress bar-pressing for intragastric (IG) delivery of doses of ethanol (25 mg/kg). The effect on oral intake of ethanol may not be attributed to a taste factor, e.g., a decreased palatability of the ethanol solution. The same dose of FLA 57 did not suppress responding for IG doses of sweet milk. There was not an impairment of appetitive behavior in general through some nonspecific depressant or toxic action. The primary reinforcing action of ethanol, when used to establish a buzzer as a conditioned reinforcer through repeated pairings, was blocked if FLA 57 was given before pairings. This was evidenced by a failure of such rats to bar-press above the baseline level in a later test of conditioned reinforcement, which contrasted with the increased responding seen for rats receiving saline instead of FLA 57 before ethanol. Previous findings on oral ethanol were supported and that FLA 57 can impair the mechanism by which ethanol produces positive reinforcement in rats was confirmed.