Borrelia burgdorferi: Carbon Metabolism and the Tick-Mammal Enzootic Cycle.
Borrelia burgdorferi: Carbon Metabolism and the Tick-Mammal Enzootic Cycle.
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DOI：
10.1128/microbiolspec.mbp-0011-2014
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发表时间：
2015-06
影响因子：
3.7
通讯作者：
Schwartz I
中科院分区：
文献类型：
--
作者：
Corona A;Schwartz I
伯氏疏螺旋体（Borrelia burgdorferi）是莱姆病的螺旋体病原体，是一种人畜共患病原体，维持在自然循环中，通常涉及哺乳动物宿主和蜱虫物种的蜱媒介。在地方性动物循环的每个阶段，伯氏疏螺旋体暴露在温度、pH值、小分子和最重要的营养来源不同的环境中。伯氏疏螺旋体的代谢能力受到高度限制，因为它不含三羧酸循环、氧化磷酸化或任何碳水化合物、氨基酸或脂质的重新生物合成途径。因此，伯氏疏螺旋体仅依靠糖酵解产生ATP，完全依赖于细胞外来源的营养物质和辅助因子的运输。本文描述了伯氏疏螺旋体碳水化合物摄取和利用的途径。这些途径的调节在不同阶段的地方性动物循环进行了讨论。此外，还提出了螺旋体在地方病循环中通过糖酵解途径对营养通量进行微分控制的模型。
Borrelia burgdorferi, the spirochetal agent of Lyme disease is a zoonotic pathogen that is maintained in a natural cycle that typically involves mammalian reservoir hosts and a tick vector of the Ixodes species. During each stage of the enzootic cycle B. burgdorferi is exposed to environments that differ in temperature, pH, small molecules, and most importantly, nutrient sources. B. burgdorferi has a highly restricted metabolic capacity as it does not contain a tricarboxylic acid cycle, oxidative phosphorylation or any pathways for de novo biosynthesis of carbohydrates, amino acids or lipids. Thus, B. burgdorferi relies solely on glycolysis for ATP production and is completely dependent on the transport of nutrients and cofactors from extracellular sources. Herein, pathways for carbohydrate uptake and utilization in B. burgdorferi are described. Regulation of these pathways during the different phases of the enzootic cycle is discussed. In addition, a model for differential control of nutrient flux through the glycolytic pathway as the spirochete transits through the enzootic cycle is presented.