Expression of the novel Snai-related zinc-finger transcription factor gene Smuc during mouse development.
Expression of the novel Snai-related zinc-finger transcription factor gene Smuc during mouse development.
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DOI：
10.3892/ijmm.15.6.945
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发表时间：
2005-06
影响因子：
5.4
通讯作者：
Xin Zhuge;H. Kataoka;Makoto Tanaka;T. Murayama;T. Kawamoto;H. Sano;Kiyonori Togi;R. Yamauchi;Y. Ueda;Yang Xu;S. Nishikawa;T. Kita;M. Yokode
中科院分区：
文献类型：
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作者：
Xin Zhuge;H. Kataoka;Makoto Tanaka;T. Murayama;T. Kawamoto;H. Sano;Kiyonori Togi;R. Yamauchi;Y. Ueda;Yang Xu;S. Nishikawa;T. Kita;M. Yokode
Snai相关蛋白是锌指转录因子，在细胞命运决定中起重要作用。我们以前克隆了一个新的蜗牛相关基因称为蜗牛相关的肌细胞转录因子（Smuc），或最近，作为蜗牛同源物3（Snai3）。在本研究中，我们研究了Smuc的功能作用，使用原位杂交分析在小鼠发育的各个阶段。直到交配后12.5天（dpc）才检测到Smuc。它的表达在骨骼肌和胸腺中观察到13.5和15.5 dpc，分别，这些仍然是Smuc表达的主要网站，直到出生后第2天。在心脏、大血管、肺、肝、肾或脑中未观察到Smuc表达。这些结果表明，Smuc可能参与骨骼肌和胸腺的形态发生在相对较晚的阶段的发展。
The Snai-related proteins are zinc-finger transcription factors that play important roles in cell-fate determination. We previously cloned a novel Snai-related gene known as snail-related transcription factor of muscle cells (Smuc) or, more recently, as snail homologue 3 (Snai3). In the present study, we investigated the functional roles of Smuc using in situ hybridization analysis at various stages of mouse development. Smuc was not detected until 12.5 days post-coitus (dpc). Its expression was observed in the skeletal muscles and thymus at 13.5 and 15.5 dpc, respectively, and these remained the major sites of Smuc expression until postnatal day 2. No Smuc expression was observed in the heart, large vessels, lungs, liver, kidney or brain. These results indicate that Smuc might be involved in the morphogenesis of the skeletal muscles and thymus at a relatively late stage of mouse development.