COVID-19 in critically ill patients in North Brabant, the Netherlands: Patient characteristics and outcomes
COVID-19 in critically ill patients in North Brabant, the Netherlands: Patient characteristics and outcomes
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DOI：
10.1016/j.jcrc.2020.08.001
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发表时间：
2020-12-01
影响因子：
3.7
通讯作者：
de Jager, C. P. C.
中科院分区：
文献类型：
--
作者：
Aleva, F. E.;van Mourik, L.;de Jager, C. P. C.
目的：自 SARS-CoV-2 大流行以来，各国因 2019 年冠状病毒病 (COVID-19) 重症患者而不堪重负。由于 ICU 容量有限，我们对荷兰的重症 COVID-19 患者进行了特征分析。方法：在本病例系列中，纳入了 2020 年 3 月 9 日至 4 月 7 日入住 Jeroen Bosch 医院 ICU 的 COVID-19 患者。通过对鼻咽拭子采集的标本进行 RT-PCR 检测呈阳性结果证实了 COVID-19。从病历中提取临床数据。结果：连续纳入的 50 名重症 COVID-19 患者的平均年龄为 65 +/- 10 岁，平均 BMI 为 29 +/- 4.7，其中 66% 为男性。 78% 的患者患有 >= 1 种合并症，34% 患有高血压。 96% 的患者需要机械通气，80% 的患者采用俯卧位通气。 36% 的患者发现静脉血栓栓塞。 74% 的患者存活并成功从 ICU 出院，其余 26% 死亡（中位随访 86 天）。幸存者的有创通气时间为 15 天（IQR 12-31）。 结论：我们人群中 COVID-19 危重患者的生存率明显优于之前报道的情况。血栓并发症很常见，值得临床关注。 (C) 2020 作者。由爱思唯尔公司出版
Purpose: Since the SARS-CoV-2 pandemic, countries are overwhelmed by critically ill Coronavirus disease 2019 (COVID-19) patients. As ICU capacity becomes limited we characterized critically ill COVID-19 patients in the Netherlands.Methods: In this case series, COVID-19 patients admitted to the ICU of the Jeroen Bosch Hospital were included from March 9 to April 7, 2020. COVID-19 was confirmed by a positive result by a RT-PCR of a specimen collected by nasopharyngeal swab. Clinical data were extracted from medical records.Results: The mean age of the 50 consecutively included critically ill COVID-19 patients was 65 +/- 10 years, the mean BMI was 29 +/- 4.7 and 66% were men. Seventy-eight percent of patients had >= 1 comorbidity, 34% had hypertension. Ninety-six percent of patients required mechanical ventilation and 80% were ventilated in prone position. Venous thromboembolism was recognized in 36% of patients. Seventy-four percent of patients survived and were successfully discharged from the ICU, the remaining 26% died (median follow up 86 days). The length of invasive ventilation in survivors was 15 days (IQR 12-31).Conclusions: The survival rate of COVID-19 critically ill patients in our population is considerably better than previously reported. Thrombotic complications are commonly found and merit clinical attention. (C) 2020 The Authors. Published by Elsevier Inc.