Quantification of drug-loaded magnetic nanoparticles in rabbit liver and tumor after in vivo administration
Quantification of drug-loaded magnetic nanoparticles in rabbit liver and tumor after in vivo administration
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DOI：
10.1016/j.jmmm.2009.02.068
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发表时间：
2009-05-01
影响因子：
2.7
通讯作者：
Alexiou, Christoph
中科院分区：
文献类型：
--
作者：
Tietze, Rainer;Jurgons, Roland;Alexiou, Christoph
磁性纳米粒子在生物医学领域的应用已经有30多年的历史。开发具有生物相容性和靶向性的纳米给药系统是医学研究的迫切需要，特别是在治疗肿瘤和血管疾病方面。我们使用药物标记的磁性氧化铁纳米颗粒，将其吸引到具有外部磁场的兔实验肿瘤（磁性药物靶向，MDT）。本研究的目的是通过磁弛豫法检测和量化磁性纳米颗粒的生物分布。该研究显示，与静脉内给药相比，动脉内应用和MDT后肿瘤中的纳米颗粒量更高。(c)2009 Elsevier B.V.保留所有权利。
Magnetic nanoparticles have been investigated for biomedical applications for more than 30 years. The development of biocompatible nanosized drug delivery systems for specific targeting of therapeuticsis imminent in medical research, especially for treating cancer and vascular diseases. We used drug labeled magnetic iron oxide nanoparticles, which were attracted to an experimental tumor in rabbits with an external magnetic field (magnetic drug targeting, MDT). Aim of this study was to detect and quantify the biodistribution of the magnetic nanoparticles by magnetorelaxometry. The study shows higher amount of nanoparticles in the tumor after intraarterial application and MDT compared to intravenous administration. (c) 2009 Elsevier B.V. All rights reserved.