Bacterial microcompartment organelles: protein shell structure and evolution.

Bacterial microcompartment organelles: protein shell structure and evolution.
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细菌微型室内细胞器:蛋白质壳的结构和进化。

DOI:
10.1146/annurev.biophys.093008.131418
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发表时间:
2010
影响因子:
12.4
通讯作者:
Tanaka S
Tanaka S
中科院分区:
生物学1区
文献类型:
--
作者:
Yeates TO;Crowley CS;Tanaka S

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一些细菌含有细胞器或微室,由一个大的病毒粒子样蛋白质外壳组成,包裹着顺序作用的酶。这些有组织的微室有助于增强或保护细胞内的关键代谢途径。各种各样的细菌微室提供不同的代谢功能,从二氧化碳固定到小有机分子的降解。然而,它们共享一个进化相关的外壳,这是由一个广泛分布在细菌王国的保守蛋白质结构域定义的。对许多这些细菌微室壳蛋白的结构研究阐明了壳的结构,并强调了其在控制分子进出微室的转运中的关键作用。目前的结构,进化和机制的想法进行了讨论,以及基因组研究,以探索这一家族的细菌细胞器的功能和多样性。
Some bacteria contain organelles or microcompartments consisting of a large virion-like protein shell encapsulating sequentially acting enzymes. These organized microcompartments serve to enhance or protect key metabolic pathways inside the cell. The variety of bacterial microcompartments provide diverse metabolic functions, ranging from CO2 fixation to the degradation of small organic molecules. Yet they share an evolutionarily related shell, which is defined by a conserved protein domain that is widely distributed across the bacterial kingdom. Structural studies on a number of these bacterial microcompartment shell proteins are illuminating the architecture of the shell and highlighting its critical role in controlling molecular transport into and out of microcompartments. Current structural, evolutionary, and mechanistic ideas are discussed, along with genomic studies for exploring the function and diversity of this family of bacterial organelles.
DOI: 10.1002/pro.272
发表时间: 2009-12-01
期刊: PROTEIN SCIENCE
影响因子: 8
作者:
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