CONCERNING THE THERMODYNAMICS OF MOLECULAR RECOGNITION IN AQUEOUS AND ORGANIC MEDIA - EVIDENCE FOR SIGNIFICANT HEAT-CAPACITY EFFECTS
CONCERNING THE THERMODYNAMICS OF MOLECULAR RECOGNITION IN AQUEOUS AND ORGANIC MEDIA - EVIDENCE FOR SIGNIFICANT HEAT-CAPACITY EFFECTS
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DOI：
10.1021/jo00296a038
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发表时间：
1990-04-27
影响因子：
3.6
通讯作者：
DOUGHERTY, DA
中科院分区：
文献类型：
--
作者：
STAUFFER, DA;BARRANS, RE;DOUGHERTY, DA
Variable-temperature binding studies are used to evaluate the thermodynamics of molecular recognition of a variety of guests by macrocyclic, cyclophane hosts. In both organic (CDCl3) and aqueous media, significant heat capacity effects are evident. Curvature in the van''t Hoff plots can be well-modeled by assuming a constant value for .DELTA.Cp.degree., and statistical analysis reveals a meaningful improvement in the correlation when .DELTA.Cp.degree. is included. Trends in the values for .DELTA.H.degree.298 and .DELTA.S.degree.298 reveal a predominantly enthalpic origin for the "cation-.PI." effect, which involves the stabilization of a positive charge by the electron-rich of an aromatic ring.
