Insight into mithramycin disruption of ETS transcription leads to improved understanding of more selective analogs.
Insight into mithramycin disruption of ETS transcription leads to improved understanding of more selective analogs.
复制标题
深入了解光神霉素对 ETS 转录的破坏可以提高对更具选择性的类似物的理解。
DOI：
10.1016/j.str.2021.03.010
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
O'Keefe,BarryR
中科院分区：
文献类型：
--
作者：
Woldemichael,GirmaM;O'Keefe,BarryR
Fusion products with the ETS family of transcription factors play critical roles in the etiology of several cancers. In this issue ofStructure, Hou et al. (2020) provide insight into allosteric mechanisms by which mithramycin and its analogs perturb protein-DNA interactions in higher-order complexes at a DNA enhancer site.
影响因子：
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作者：
Meisel Sharon S;Pozniak Y;Geiger T;Werner H
通讯作者：
Werner H
影响因子：
10.3
作者：
Grohar, Patrick J.;Woldemichael, Girma M.;Helman, Lee J.
通讯作者：
Helman, Lee J.