Does transcription factor induced pluripotency accurately mimic embryo derived pluripotency?
Does transcription factor induced pluripotency accurately mimic embryo derived pluripotency?
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DOI：
10.1016/j.gde.2012.07.003
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发表时间：
2012-10
影响因子：
4
通讯作者：
Lowry, William E.
中科院分区：
文献类型：
--
作者：
Lowry, William E.
当Takahashi和Yamanaka首次证明只有四种转录因子可以将成纤维细胞重编程为多能干细胞时，出现的第一波数据集中在这些诱导多能干细胞（iPSC）与胚胎来源的多能干细胞（ESC）的相似性。下一波数据集中在确定iPSCs和ESCs之间的差异程度。现在的重点是调整过程，以产生更类似于ESC的iPSC。由于基于转录因子的重编程允许从任何供体细胞产生几乎任何类型的细胞，因此显然对该技术作为基础发育生物学和临床应用的工具存在巨大兴趣。在这篇综述中，我将试图总结有助于区分这些类型的多能干细胞的数据，并推测差异的任何后果。
When Takahashi and Yamanaka first demonstrated that just four transcription factors could reprogram a fibroblast to a pluripotent stem cell, the first wave of data to emerge focused on how similar these induced pluripotent stem cells (iPSCs) were to embryo-derived pluripotent stem cells (ESCs). The next wave of data focused on determining the degree of difference between iPSCs and ESCs. Now the focus is on tweaking the process to generate iPSCs that are more similar to ESCs. Because transcription factor based reprogramming allows for nearly any type of cell to be created from any donor cell, there is obviously enormous interest in this technique as a tool for both basic developmental biology and for clinical applications. In this review, I will attempt to summarize the data that serve to distinguish these types of pluripotent stem cells and speculate on any ramifications of the differences.
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