Effect of surfactants on the formation and characterization of a new type of colloidal drug delivery system: Nanostructured lipid carriers
Effect of surfactants on the formation and characterization of a new type of colloidal drug delivery system: Nanostructured lipid carriers
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DOI：
10.1016/j.colsurfa.2007.08.005
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发表时间：
2008-02-15
影响因子：
5.2
通讯作者：
Xu, Lu
中科院分区：
文献类型：
--
作者：
Han, Fei;Li, Sanming;Xu, Lu
纳米结构脂质载体（NLC）由固体脂质和液体脂质组成，是一种新型的胶体药物递送系统，具有提高载药量和释放性能的优点。表面活性剂在 NLC 的形成和表征中发挥着重要作用。为了研究表面活性剂对NLC性能的影响，在没有模型药物的情况下使用四种类型的表面活性剂及其混合物，从而避免表面活性剂与药物之间的相互作用。采用热高压均质法制备NLC，并研究了NLC的理化性质，如粒径分布、zeta电位和DSC分析。结果表明，脱氧胆酸钠(SDC)等离子表面活性剂在制剂中的乳化效率明显较低。然而，它增加了纳米颗粒的 zeta 电位，从而提高了系统的物理稳定性。非离子乳化剂，特别是泊洛沙姆 188，提供额外的空间稳定作用，避免纳米粒子在胶体系统中聚集。该研究配方结合了离子表面活性剂（SDC）、非离子乳化剂（泊洛沙姆188和Tween-80）、卵磷脂等四种添加剂，获得了稳定性良好的NLC药物递送系统，在4℃下可以稳定1年以上而不发生相分离。（c）2007 Elsevier B.V.版权所有。
Nanostructured lipid carriers (NLC) consisted of solid lipid and liquid lipid are a new type of colloidal drug delivery system, which offer the advantage of improved drug loading capacity and release properties. Surfactants play important roles in the formation and characterization of NLC. In order to investigate the influence of surfactants on properties of NLC, four types of surfactants and their mixtures were used in the absence of model drugs thereby avoiding the interaction between surfactants and drugs. The hot high-pressure homogenization method was employed to produce NLC and the physicochemical properties of NLC, such as particle size distribution, zeta potential and DSC analysis were investigated. The results indicated that ionic surfactants such as sodium deoxycholate (SDC), showed obviously low emulsification efficiency in the preparation. However, it increased the zeta potential of nanoparticles leading to improve the physical stability of the system. Non-ionic emulsifier, especially Poloxamer 188, offered additional steric stabilization effect avoiding aggregation of the nanoparticles in the colloidal system. The formulation in the study combined four types of additives including ionic surfactant (SDC), non-ionic emulsifier (Poloxamer 188 and Tween-80), and Lecithin to obtain favorably stable NLC drug delivery system, which could stabilize for more than 1 year without phase separation at 4 degrees C. (c) 2007 Elsevier B.V. All rights reserved.