Altered Functional Organization within and between Resting-State Networks in Chronic Subcortical Infarction
Altered Functional Organization within and between Resting-State Networks in Chronic Subcortical Infarction
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DOI：
10.1038/jcbfm.2013.238
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发表时间：
2014-01
影响因子：
6.3
通讯作者：
Caihong Wang;W. Qin;Jing Zhang;Tian Tian-Tian;Y. Li;Liangliang Meng;Xuejun Zhang;Chunshui Yu
中科院分区：
文献类型：
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作者：
Caihong Wang;W. Qin;Jing Zhang;Tian Tian-Tian;Y. Li;Liangliang Meng;Xuejun Zhang;Chunshui Yu
本研究旨在探讨功能连接（FC）的变化，在每个静息状态网络（RSN）和RSN之间的皮质下卒中患者的整体运动功能恢复良好。11个有意义的RSN确定通过功能磁共振成像数据从25皮质下卒中患者和22名正常对照使用独立成分分析。与正常对照组相比，脑卒中患者在感觉运动（SMN），视觉（VN），听觉（AN），背侧注意（DAN）和默认模式（DMN）网络中表现出增加的内部网络FC;他们还表现出额顶网络（FPN）和前部DMN中的内部网络FC减少。卒中患者显示从对照组的无FC到VN和AN之间以及VN和SMN之间的负网络间FC的转变。与正常对照组相比，卒中患者也表现出减弱的阳性（前和后DMN;后DMN和右FPN）或阴性（AN和右FPN;后DMN和背侧SMN）网络间FC。我们认为，皮层下中风可能会引起多个功能网络的连接变化，不仅影响RSN内的内部网络FC，但也影响这些RSN之间的网络FC。
This study aimed to investigate the changes in functional connectivity (FC) within each resting-state network (RSN) and between RSNs in subcortical stroke patients who were well recovered in global motor function. Eleven meaningful RSNs were identified via functional magnetic resonance imaging data from 25 subcortical stroke patients and 22 normal controls using independent component analysis. Compared with normal controls, stroke patients exhibited increased intranetwork FC in the sensorimotor (SMN), visual (VN), auditory (AN), dorsal attention (DAN), and default mode (DMN) networks; they also exhibited decreased intranetwork FC in the frontoparietal network (FPN) and anterior DMN. Stroke patients displayed a shift from no FC in controls to negative internetwork FC between the VN and AN as well as between the VN and SMN. Stroke patients also exhibited weakened positive (anterior and posterior DMN; posterior DMN and right FPN) or negative (AN and right FPN; posterior DMN and dorsal SMN) internetwork FC when compared with normal controls. We suggest that subcortical stroke may induce connectivity changes in multiple functional networks, affecting not only the intranetwork FC within RSNs but also the internetwork FC between these RSNs.