Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function
Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function
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DOI：
10.1016/j.jacc.2006.06.057
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发表时间：
2006-10-17
影响因子：
24
通讯作者：
Ros, Emilio
中科院分区：
文献类型：
--
作者：
Cortes, Berenice;Nunez, Isabel;Ros, Emilio
我们试图调查是否除了核桃或橄榄油脂肪餐后血管活性，脂蛋白，氧化和内皮激活的标志物，血浆不对称二甲基精氨酸（ADMA）的差异影响，与地中海饮食相比，核桃饮食已被证明可以改善高胆固醇血症患者的内皮功能。我们假设，核桃将扭转餐后内皮功能障碍与消费的脂肪meal.METHODS我们随机交叉设计12名健康受试者和12例高胆固醇血症患者2高脂肪餐序列，其中25克橄榄油或40克核桃已被添加。两种试验餐均含有80 g脂肪和35%饱和脂肪酸，每餐的消耗间隔1周。静脉穿刺和超声测量肱动脉endothetial功能进行后，空腹和4小时后，测试mean.Results在两个研究组，流量介导的扩张（FMD）是更糟糕的橄榄油餐后比核桃餐（p = 0.006，时间周期的相互作用）。空腹而非餐后甘油三酯浓度与FMD呈负相关（r = -0.324; p = 0.024）。两餐后，血流非依赖性扩张和血浆ADMA浓度不变，氧化低密度脂蛋白浓度降低（p = 0.051）。可溶性炎症细胞因子和粘附分子的血浆浓度下降（p < 0.01）独立于膳食类型，除了E-选择素，其下降更多（p = 0.033）后核桃meal.Conclusions添加核桃到高脂肪餐急性改善FMD独立于氧化，炎症，或ADMA的变化。核桃和橄榄油都能保持内皮细胞的保护性表型。
OBJECTIVES We sought to investigate whether the addition of walnuts or olive oil to a fatty meal have differential effects on postprandial vasoactivity, lipoproteins, markers of oxidation and endothetial activation, and plasma asymmetric dimethylarginine (ADMA).BACKGROUND Compared with a Mediterranean diet, a walnut diet has been shown to improve endothelial function in hypercholesterolemic patients. We hypothesized that walnuts would reverse postprandial endothelial dysfunction associated with consumption of a fatty meal.METHODS We randomized in a crossover design 12 healthy subjects and 12 patients with hypercholesterolemia to 2 high-fat meal sequences to which 25 g olive oil or 40 g walnuts had been added. Both test meals contained 80 g fat and 35% saturated fatty acids, and consumption of each meal was separated by 1 week. Venipunctures and ultrasound measurements of brachial artery endothetial function were performed after fasting and 4 h after test meals.RESULTS In both study groups, flow-mediated dilation (FMD) was worse after the olive oil meal than after the walnut meal (p = 0.006, time-period interaction). Fasting, but not postprandial, triglyceride concentrations correlated inversely with FMD (r = -0.324; p = 0.024). Flow-independent dilation and plasma ADMA concentrations were unchanged, and the concentration of oxidized low-density lipoproteins decreased (p = 0.051) after either meal. The plasma concentrations of soluble inflammatory cytokines and adhesion molecules decreased (p < 0.01) independently of meal type, except for E-selectin, which decreased more (p = 0.033) after the walnut meal.CONCLUSIONS Adding walnuts to a high-fat meal acutely improves FMD independently of changes in oxidation, inflammation, or ADMA. Both walnuts and olive oil preserve the protective phenotype of endothelial cells.