EVALUATION OF THE MACROCYCLIC ANTIBIOTIC VANCOMYCIN AS A CHIRAL SELECTOR FOR CAPILLARY ELECTROPHORESIS
EVALUATION OF THE MACROCYCLIC ANTIBIOTIC VANCOMYCIN AS A CHIRAL SELECTOR FOR CAPILLARY ELECTROPHORESIS
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DOI：
10.1002/chir.530060609
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发表时间：
1994-01-01
期刊：
影响因子：
2
通讯作者：
CHEN, JR
中科院分区：
文献类型：
--
作者：
ARMSTRONG, DW;RUNDLETT, KL;CHEN, JR
万古霉素是一个家族的相关大环糖肽抗生素，发现了科学家在礼来公司在20世纪50年代。它已被用于治疗严重的葡萄球菌感染，特别是当细菌对其他抗生素产生耐药性时。万古霉素是一种天然存在的手性化合物，具有许多立体中心。此外，它含有已知可用于对映选择性相互作用的多种官能团（例如，氢键基团、疏水袋、芳族基团、酰胺键等）。万古霉素的理化性质，包括其在溶液中的稳定性，进行了讨论，因为它们属于毛细管电泳。超过100个外消旋体被解决，包括许多非甾体类药物，化合物和N-衍生的氨基酸。这些化合物中的许多具有非常高的分辨率因子。讨论了实验条件的优化以及不同实验参数对手性拆分的影响。(C)1994 Wiley-Liss，Inc.
Vancomycin is one of a family of related macrocyclic glycopeptide antibiotics that were discovered by scientists at the Eli Lilly Company in the 1950s. It has been used to treat severe staphylococcal infections, particularly when bacterial resistance to other antibiotics has developed. Vancomycin is a naturally occurring chiral compound and has a number of stereogenic centers. Furthermore, it contains a variety of functionalities that are known to be useful for enantioselective interactions (e.g., hydrogen bonding groups, hydrophobic pockets, aromatic groups, amide linkages, etc.). The physicochemical properties of vancomycin, including its stability in solution, are discussed as they pertain to capillary electrophoresis. Over 100 racemates were resolved including many nonsteroidal antiinflammatory drugs, antineoplastic compounds and N-derivatized amino acids. Many of these compounds had very high resolution factors. Optimization and the effect of different experimental parameters on the enantioselective separations are discussed. (C) 1994 Wiley-Liss, Inc.