The strength of transcription-factor binding modulates co-variation in transcriptional networks.
The strength of transcription-factor binding modulates co-variation in transcriptional networks.
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转录因子结合的强度调节转录网络中的共变。
DOI：
10.1016/j.tig.2009.12.005
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Hahn,MatthewW
中科院分区：
文献类型：
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作者：
Nuzhdin,SergeyV;Rychkova,Anna;Hahn,MatthewW
转录组的一个可观的部分在个体之间的表达水平不同。转录因子（TF）表达和DNA结合导致细胞特异性激活和下游靶点的抑制，TF表达水平在个体之间存在差异。然而，目前尚不清楚DNA结合的强度如何转化为个别TF的调控控制，或是否有一组不同的结合基序被用于强调控模块。在这里，我们整合了两个公开的数据集在果蝇，以及进行新的分析，以解决这些问题。
An appreciable fraction of the transcriptome differs in level of expression among individuals. Transcription factor (TF) expression and DNA binding causes cell-specific activation and repression of downstream targets, and TF expression levels vary across individuals. However, it is not clear how the strength of DNA binding for individual TFs translates into regulatory control, or whether a different set of binding motifs is used for strongly regulated modules. Here we integrate two publicly available data sets inDrosophila melanogaster, as well as conduct novel analyses, to address these questions.