Deciphering gene expression regulatory networks
Deciphering gene expression regulatory networks
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DOI：
10.1016/s0959-437x(02)00277-0
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发表时间：
2002-04-01
影响因子：
4
通讯作者：
Young, RA
中科院分区：
文献类型：
--
作者：
Wyrick, JJ;Young, RA
在过去的一年里，我们对控制真核生物酿酒酵母基因表达的调控网络的理解取得了长足的进步。一些基因组工具的开发和使用，包括全基因组定位和表达分析，推动了这一进展。此外，已经设计了各种计算算法来挖掘共同调控基因中保守的调控基序的基因组序列。最近对控制细胞周期的遗传网络的描述表明，这些方法在破译真核细胞中的基因表达调控网络方面具有巨大的潜力。
In the past year, great strides have been made in our understanding of the regulatory networks that control gene expression in the model eukaryote Saccharomyces cerevisiae. The development and use of a number of genomic tools, including genome-wide location and expression analysis, has fueled this progress. In addition, a variety of computational algorithms have been devised to mine genomic sequence for conserved regulatory motifs in co-regulated genes. The recent description of the genetic network controlling the cell cycle illustrates the tremendous potential of these approaches for deciphering gene expression regulatory networks in eukaryotic cells.