REINNERVATION OF SKELETAL-MUSCLE - A COMPARISON OF NERVE IMPLANTATION WITH NEUROMUSCULAR PEDICLE TRANSFER IN AN ANIMAL-MODEL
REINNERVATION OF SKELETAL-MUSCLE - A COMPARISON OF NERVE IMPLANTATION WITH NEUROMUSCULAR PEDICLE TRANSFER IN AN ANIMAL-MODEL
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DOI：
10.1177/000348948709600203
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发表时间：
1987-03-01
影响因子：
1.4
通讯作者：
CUMMINGS, CW
中科院分区：
文献类型：
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作者：
MEIKLE, D;TRACHY, RE;CUMMINGS, CW
近年来，人们对重新支配瘫痪肌肉的可能性越来越感兴趣，特别是面部和喉部的肌肉。对于不同方法的相对有效性存在争议。本研究旨在比较直接神经植入与神经肌肉蒂转移在兔模型中的失神经支配的带状肌肉。去神经后立即和延迟一段时间后进行神经再支配。功能恢复的证据是通过长期肌电图监测的方法获得的，并通过诱发肌电图和肌张力测量以及组织学上通过脑干辣根过氧化物酶摄取证实。这两种方法的神经转移产生一致的功能神经肌肉单位，生理活动和肌肉力量与正常神经支配的控制。在神经切除和神经肌肉转移后6周内，功能恢复明显;在该模型中，两种方法均未显示出明显的优势。
In recent years there has been increased interest in the possibility of reinnervating paralyzed muscles, particularly the muscles of the face and of the larynx. There has been dispute over the relative effectiveness of different approaches. This study was undertaken to compare direct nerve implantation with the transfer of a neuromuscular pedicle using denervated strap muscles in a rabbit model. Reinnervation was carried out both immediately after denervation and after a delay period. Evidence of return of function was obtained by a method of long-term electromyographic moitoring and was confirmed electrically by evoked electromyography and muscle tension measurement and histologically by brain stem uptake by horseradish peroxidase. Both methods of nerve transfer produced consistently functional neuromuscular units, with physiological activity and muscle strength comparable with those in normally innervated controls. Return of function was apparent within 6 weeks of both nerve implanatation and neuromuscular transfer; with this model, neither method showed a clear advantage over the other.