Anti-tumor-promoting activity of the diterpene from Excoecaria agallocha.: II
Anti-tumor-promoting activity of the diterpene from Excoecaria agallocha.: II
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DOI：
10.1248/bpb.24.1440
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发表时间：
2001-12-01
影响因子：
2
通讯作者：
Tokuda, H
中科院分区：
文献类型：
--
作者：
Konoshima, T;Konishi, T;Tokuda, H
为了从天然资源中寻找有效的抗肿瘤促进剂，从大戟科植物海漆木中分离得到8个新的二萜类化合物（1-8），并研究了它们对Raji细胞中EB病毒早期抗原（EBV-EA）诱导的抑制作用。在这些化合物中，断枝烷型二萜类化合物7在使用7，12-二甲基苯并[a]蒽和12-O-十四酰基-佛波醇-13-乙酸酯的小鼠两阶段致癌试验中表现出对EBV-EA诱导的显著抑制作用和显著的抗肿瘤促进作用。
Eight new diterpenoids (1-8) have been isolated from the wood of Excoecaria agallocha (Euphorbiaceae) and their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) in Raji cells were examined to search for potent anti-tumor-promoters from natural resources. Of these compounds, the secolabdane-type diterpenoid, compound 7 exhibited a remarkable inhibitory effect on EBV-EA induction, and a significant anti-tumor-promoting effect in the mouse two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoyl-phorbol-13-acetate.