Organization of organelles and VAMP-associated vesicular transport systems in differentiating skeletal muscle cells
Organization of organelles and VAMP-associated vesicular transport systems in differentiating skeletal muscle cells
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DOI：
10.1007/s12565-014-0266-6
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发表时间：
2014
影响因子：
1.2
通讯作者：
Yuki Tajika;Maiko Takahashi;H. Ueno;T. Murakami;H. Yorifuji
中科院分区：
文献类型：
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作者：
Yuki Tajika;Maiko Takahashi;H. Ueno;T. Murakami;H. Yorifuji
囊泡转运在细胞功能和细胞分化的调节中起重要作用，并且胞内囊泡在膜组分的递送和将膜蛋白分选到细胞器和质膜中的适当结构域中起作用。关于分化细胞中囊泡转运的研究主要集中在神经元和上皮细胞上，很少有这样的研究在骨骼肌细胞上进行。骨骼肌细胞具有专门的细胞器和质膜结构域，包括T-小管、肌浆网、神经肌肉接头和肌腱接头。骨骼肌细胞的分化通过多个步骤实现，即，成肌细胞增殖、通过细胞-细胞融合形成肌管、以及肌管成熟为肌纤维。系统性囊泡转运在骨骼肌细胞的维持和发育中发挥作用。在这里，我们回顾了骨骼肌细胞分化过程中的囊泡运输系统的地图。根据形态学研究，描述了肌管中细胞器的排列特点。囊泡运输在肌管的可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体蛋白的表达谱解释。
Vesicular transport plays an important role in the regulation of cellular function and differentiation of the cell, and intracellular vesicles play a role in the delivery of membrane components and in sorting membrane proteins to appropriate domains in organelles and the plasma membrane. Research on vesicular transport in differentiating cells has mostly focused on neurons and epithelial cells, and few such studies have been carried out on skeletal muscle cells. Skeletal muscle cells have specialized organelles and plasma membrane domains, including T-tubules, sarcoplasmic reticulum, neuromuscular junctions, and myotendinous junctions. The differentiation of skeletal muscle cells is achieved by multiple steps, i.e., proliferation of myoblasts, formation of myotubes by cell–cell fusion, and maturation of myotubes into myofibers. Systematic vesicular transport is expected to play a role in the maintenance and development of skeletal muscle cells. Here, we review a map of the vesicular transport system during the differentiation of skeletal muscle cells. The characteristics of organelle arrangement in myotubes are described according to morphological studies. Vesicular transport in myotubes is explained by the expression profiles of solubleN-ethylmaleimide-sensitive factor attachment protein receptor proteins.