Conquering rheumatic diseases: are parasitic worms the answer?
Conquering rheumatic diseases: are parasitic worms the answer?
复制标题
DOI：
10.1016/j.pt.2023.06.010
复制
发表时间：
2023-08-09
影响因子：
9.6
通讯作者：
Harnett，William
中科院分区：
文献类型：
--
作者：
Buitrago，Geraldine;Harnett，Margaret M.;Harnett，William
尽管引入了新的治疗策略，风湿性疾病的管理仍然与大量未满足的临床需求相关。因此，令人感兴趣的是，最近已经变得明显的是，在这些条件和寄生虫感染的发病率之间存在全球性的反比关系，在印度的研究中，涉及类风湿性关节炎（RA）/系统性红斑狼疮（SLE）患者和丝虫线虫感染的惊人例子。这些发现反映了蠕虫是免疫系统的主要操纵者，特别是能够调节促炎反应。因此，本文的目的是考虑迄今为止在这一令人兴奋和有趣的研究领域的发现，以形成一个关于寄生蠕虫是否可以被利用来产生风湿性疾病的新疗法的意见。
Despite the introduction of novel treatment strategies, management of rheumatic disorders remains associated with substantial unmet clinical need. Of interest therefore, it has recently become apparent that there is a global inverse relationship between the incidence of such conditions and parasitic helminth infection, with striking examples involving rheumatoid arthritis (RA)/systemic lupus erythematosus (SLE) patients and filarial nematode worm infection in studies in India. Such findings reflect that helminths are master manipulators of the immune system, particularly in being able to modulate proinflammatory responses. The aim of this article is thus to consider findings to date on this exciting and intriguing research area to form an opinion on whether parasitic worms may be exploited to generate novel therapies for rheumatic diseases.