Why Observational Studies Should Be Among The Tools Used In Comparative Effectiveness Research
Why Observational Studies Should Be Among The Tools Used In Comparative Effectiveness Research
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DOI：
10.1377/hlthaff.2010.0666
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发表时间：
2010-10-01
期刊：
影响因子：
9.7
通讯作者：
Gliklich, Richard
中科院分区：
文献类型：
--
作者：
Dreyer, Nancy A.;Tunis, Sean R.;Gliklich, Richard
医生、患者和其他决策者需要获得可获得的最佳临床证据，这些证据可能来自系统评价、实验试验和观察性研究。尽管存在方法学上的挑战，但高质量的观察性研究在比较有效性研究中具有重要作用，因为它们可以解决其他方面难以或不可能研究的问题。此外，许多临床和政策决定并不需要大规模、严格的随机试验所提供的高度确定性。本文提供了见解和框架，以指导良好的决策，涉及全方位的高质量比较有效性研究技术，包括观察性研究。
Doctors, patients, and other decision makers need access to the best available clinical evidence, which can come from systematic reviews, experimental trials, and observational research. Despite methodological challenges, high-quality observational studies have an important role in comparative effectiveness research because they can address issues that are otherwise difficult or impossible to study. In addition, many clinical and policy decisions do not require the very high levels of certainty provided by large, rigorous randomized trials. This paper provides insights and a framework to guide good decision making that involves the full range of high-quality comparative effectiveness research techniques, including observational research.