Rice bran protein ameliorates diabetes, reduces fatty liver, and has renoprotective effects in Zucker Diabetic Fatty rats
Rice bran protein ameliorates diabetes, reduces fatty liver, and has renoprotective effects in Zucker Diabetic Fatty rats
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DOI：
10.1016/j.jff.2020.103981
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发表时间：
2020-07-01
影响因子：
5.6
通讯作者：
Kadowaki, Motoni
中科院分区：
文献类型：
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作者：
Kubota, Masatoshi;Watanabe, Reiko;Kadowaki, Motoni
米糠蛋白(RBP)占米糠的12.8%，其保健作用尚未完全明了。因此，我们研究了RBP对Zucker糖尿病肥胖(ZDF)大鼠糖尿病、脂肪肝和糖尿病肾病的影响。6周龄雄性ZDF大鼠以RBP或酪蛋白(C)为基础饲喂8周。饲喂RBP的大鼠体重显著增加，但脂肪库与饲喂C的大鼠没有区别。摄入RBP可显著提高大鼠的HbA1c和血浆脂联素水平。在RBP喂养的大鼠肝脏中，脂肪积累明显减少，参与糖酵解的代谢物浓度显著增加，甜菜碱和肉碱代谢显著增加。此外，喂饲RBP的大鼠的尿白蛋白和N-乙酰-β-D-氨基葡萄糖苷酶排泄量以及肾脏的组织学损害也显著降低。总而言之，与基于C的饮食相比，含有RBP的饮食可以改善大鼠的糖尿病、脂肪肝和糖尿病肾病。
The beneficial effects of rice bran protein (RBP), which comprises 12.8% of rice bran, have not been fully characterized. Therefore, the effects of RBP on diabetes, fatty liver, and diabetic nephropathy were investigated in Zucker Diabetic Fatty (ZDF) rats. Six-week-old male ZDF rats were fed RBP or casein (C)-based diets for 8 weeks. RBP-fed rats gained significantly more weight, but fat depot was not different from C-fed rats. Hemoglobin A1c and plasma adiponectin levels were significantly improved by consuming RBP rather than C. In RBP-fed rat livers, lipid accumulation was much lower, and the concentrations of metabolites involved in glycolysis, and betaine and carnitine metabolism were significantly higher. In addition, urinary albumin and Nacetyl-beta-D-glucosaminidase excretion, and histological damage in the kidney, were significantly lower in RBP-fed rats. In conclusion, an RBP-containing diet ameliorates diabetes, fatty liver, and diabetic nephropathy in rats, compared with a C-based diet.