Responses of mesenteric and renal blood flow dynamics to acute denervation in anesthetized rats
Responses of mesenteric and renal blood flow dynamics to acute denervation in anesthetized rats
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DOI：
10.1152/ajpregu.1998.275.5.r1543
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发表时间：
1998-11-01
影响因子：
2.8
通讯作者：
Salevsky, FC
中科院分区：
文献类型：
--
作者：
Abu-Amarah, I;Ajikobi, DO;Salevsky, FC
以往的研究表明，肾自动调节动态稳定肾血流量（RBF）。肾神经，特别是压力反射成分，在RBF的动态调节中的作用仍然不清楚。自动调节和肠系膜神经在上级肠系膜动脉（MBF）中的血流动态调节中的相对作用同样不清楚。在这项研究中，传递函数分析，以确定自动调节和压力反射成分的动态调节RBF和MBF在Wistar大鼠和年轻的自发性高血压大鼠（SHR）麻醉异氟醚或氟烷。Wistar大鼠表现出有效的动态自动调节MBF和RBF，SHR。肾脏（0.22 +/- 0.01 Hz）的自动调节速度快于肠道（0.13 +/- 0.01 Hz）。在肠系膜，但不是肾床，导纳相是显着的负0.25和0.7赫兹之间，和负相被废除肠系膜去神经，表明存在动脉压力感受器反射。压力反射快于自动调节。交感神经的存在无关的血压的影响，推断在两个血管床，似乎是更强的SHR比Wistar大鼠。它的结论是，生理上显着的压力反射操作肠系膜，但不是肾循环，在两个床的血流有效地稳定自动调节。
Previous studies have shown that renal autoregulation dynamically stabilizes renal blood flow (RBF). The role of renal nerves, particularly of a baroreflex component, in dynamic regulation of RBF remains unclear The relative roles of autoregulation and mesenteric nerves in dynamic regulation of blood flow in the superior mesenteric artery (MBF) are similarly unclear. In this study, transfer function analysis was used to identify autoregulatory and baroreflex components in the dynamic regulation of RBF and MBF in Wistar rats and young spontaneously hypertensive rats (SHR) anesthetized with isoflurane or halothane. Wistar rats showed effective dynamic autoregulation of both MBF and RBF, as did SHR. Autoregulation was faster in the kidney (0.22 +/- 0.01 Hz) than in the gut(0.13 +/- 0.01 Hz). in the mesenteric, but not the renal bed, the admittance phase was significantly negative between 0.25 and 0.7 Hz, and the negative phase was abrogated by mesenteric denervation, indicating the presence of an arterial baroreflex. The baroreflex was faster than autoregulation in either bed. The presence of sympathetic effects unrelated to blood pressure was inferred in both vascular beds and appeared to be stronger in the SHR than in the Wistar rats. It is concluded that a physiologically significant baroreflex operates on the mesenteric, but not the renal circulation and that blood flow in both beds is effectively stabilized by autoregulation.