pH triggered self-assembly structural transition of ionic liquids in aqueous solutions: smart use of pH-responsive additives
pH triggered self-assembly structural transition of ionic liquids in aqueous solutions: smart use of pH-responsive additives
复制标题
pH引发水溶液中离子液体的自组装结构转变：巧妙使用pH响应型添加剂
DOI：
10.1039/c5ra12010a
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发表时间：
2015-01-01
期刊：
影响因子：
3.9
通讯作者：
Wang, Jianji
中科院分区：
文献类型：
--
作者：
Wang, Huiyong;Tan, Bo;Wang, Jianji
响应于特定pH值而经历形态转变的智能自组装流体的产生可以允许药物递送剂的增强的积累。在这项工作中，我们开发了一系列的pH响应性流体组成的1-烷基-3-甲基咪唑溴[Cnmim]Br（n = 12，14）和pH响应性水溶助长剂邻苯二甲酸氢钾（[C6 H4 COOKCOOH]），磺基水杨酸钠（[C6 H3 OHCOOHSO 3 Na]），或间羧基苯磺酸钠（[C6 H4 COOHSO 3 Na]）。通过表面张力、动态光散射、低温透射电子显微镜、小角X射线散射、偏光显微镜和核磁共振谱等方法研究了这些离子液体在水溶助长剂水溶液中的自组装结构。结果表明，离子液体[Cnmim]Br（n = 12，14）在加入水溶助长剂后可自组装成囊泡，且随着溶液pH值的变化，可观察到从球形胶束到囊泡的可逆转变.离子液体自组装结构的转变被认为是由水溶助长剂的分子结构和亲水/疏水性的变化所驱动的。
The creation of smart self-assembling fluids that undergo a morphological transition in response to a specific pH value can allow for the enhanced accumulation of drug delivery agents. In this work, we developed a series of pH-responsive fluids composed of 1-alkyl-3-methylimidazolium bromide [Cnmim]Br (n = 12, 14) and one of the pH-responsive hydrotropes of potassium hydrogen phthalate ([C6H4COOKCOOH]), sodium sulfosalicylate ([C6H3OHCOOHSO3Na]), or m-carboxylbenzenesulfonate sodium ([C6H4COOHSO3Na]). The self-assembled structures of these ILs in aqueous hydrotrope solutions were investigated by surface tension, dynamic light scattering, cryogenic-transmission electron microscopy, small-angle X-ray scattering, polarized optical microscopy, and nuclear magnetic resonance spectroscopy. It was found that the ionic liquids, [Cnmim]Br (n = 12, 14), could self-assemble into vesicles with the addition of the hydrotrope, and a reversible transition between spherical micelles and vesicles was observed with the change of solution pH value. The transition in the self-assembled structures of the ILs is suggested to be driven by the change in the molecular structure and hydrophilicity/hydrophobicity of the hydrotrope.