Impaired safety signal learning may be a biomarker of PTSD.
Impaired safety signal learning may be a biomarker of PTSD.
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DOI：
10.1016/j.neuropharm.2011.02.023
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发表时间：
2012-02
影响因子：
4.7
通讯作者：
Davis M
中科院分区：
文献类型：
--
作者：
Jovanovic T;Kazama A;Bachevalier J;Davis M
恐惧反应失调是创伤后应激障碍（PTSD）患者的标志性临床表现之一。这些患者表现出恐惧的过度泛化，并且在安全存在的情况下无法抑制恐惧反应。在这里，我们总结了我们最近的研究结果，使用条件判别范式，评估安全信号处理（AX+/BX-）在战斗和平民PTSD人群。总体而言，PTSD受试者表现出缺乏安全信号学习和无法调节的恐惧反应与安全线索。然后，我们回顾了人类和非人类的恐惧表达和抑制的神经生物学研究，以便为使用反向翻译程序的初步研究提供背景，其中在恒河猴中使用相同的AX+/BX-范式。
A dysregulated fear response is one of the hallmark clinical presentations of patients suffering from posttraumatic stress disorder (PTSD). These patients show overgeneralization of fear and in tandem an inability to inhibit fear responses in the presence of safety. Here, we summarize our recent findings using a conditional discrimination paradigm, which assesses safety signal processing (AX+/BX−) in combat and civilian PTSD populations. Overall, PTSD subjects demonstrate a lack of safety signal learning and an inability to modulate the fear responses with safety cues. We then review studies of the neurobiology of fear expression and inhibition in humans and non-humans, in order to provide a background for preliminary studies using reverse translation procedures in which the same AX+/BX− paradigm was used in rhesus macaques.