INTERCHANGEABILITY OF STRESS AND AMPHETAMINE IN SENSITIZATION
INTERCHANGEABILITY OF STRESS AND AMPHETAMINE IN SENSITIZATION
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DOI：
10.1126/science.7188649
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
KOCAN, D
中科院分区：
文献类型：
--
作者：
ANTELMAN, SM;EICHLER, AJ;KOCAN, D
鉴于安非他明和压力的行为，生化和电生理效应之间的相似性，我们测试了假设，介绍了一个应激源，轻度的尾部压力，可以敏感的动物安非他明的后期效果，反之亦然。我们的研究结果支持了这一假设，并表明，安非他明和至少一些应激源可能是可互换的能力，以诱导致敏。这些数据提出了一种可能性，即压力可能是导致安非他明精神病和某些形式的精神分裂症的共同变量。
In view of similarities between the behavioral, biochemical, and electrophysiological effects of amphetamine and stress, we tested the hypothesis that presentation of a stressor, mild tail pressure, can sensitize an animal to the later effects of amphetamine, and vice versa. Our findings supported this hypothesis and suggest that amphetamine and at least some stressors may be interchangeable in their ability to induce sensitization. The data raise the possibility that stress might be a common variable contributing to both amphetamine psychosis and some forms of schizophrenia.