Osteoarthritis and cartilage: the role of cytokines.
Osteoarthritis and cartilage: the role of cytokines.
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DOI：
10.1007/s11926-000-0021-y
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发表时间：
2000-12-01
影响因子：
5
通讯作者：
Goldring, M B
中科院分区：
文献类型：
--
作者：
Goldring, M B
骨关节炎的发病机制涉及多种原因，包括机械、生化和遗传因素，这些因素导致关节软骨合成和破坏的失衡。白介素1和肿瘤坏死因子α是参与疾病发生和发展的主要促炎和分解代谢细胞因子。其他促炎细胞因子可能会放大或调节这一过程，而抗炎细胞因子可能会抵消组织的破坏和炎症，相反，在骨关节炎组织中经常检测到抗炎细胞因子。本文综述了细胞因子在骨关节炎发病机制中的作用，特别强调了培养和动物模型中的发现如何反映在人类疾病过程中。
The pathogenesis of osteoarthritis involves multiple etiologies, including mechanical, biochemical, and genetic factors that contribute to the imbalance in the synthesis and destruction of articular cartilage. It is now well documented that interleukin-1 and tumor necrosis factor-alpha are the predominant proinflammatory and catabolic cytokines involved in disease initiation and progression. Other proinflammatory cytokines may amplify or modulate this process, whereas anti-inflammatory cytokines, which are often detected, paradoxically, in osteoarthritis tissues, may counteract the tissue destruction and inflammation. This review focuses on the role of cytokines in the pathogenesis of osteoarthritis with special emphasis on how findings in culture and animal models may be reflected in the human disease process.