Synthesis of biocompatible dendrimers with a peripheral network formed by linking of polymerizable groups
Synthesis of biocompatible dendrimers with a peripheral network formed by linking of polymerizable groups
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DOI：
10.1016/j.polymer.2005.01.004
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发表时间：
2005-02-24
期刊：
影响因子：
4.6
通讯作者：
Kono, K
中科院分区：
文献类型：
--
作者：
Haba, Y;Harada, A;Kono, K
为了生产具有生物相容性表面的单分子纳米胶囊，我们制备了第四代聚酰胺胺树状分子，该树状分子具有平均分子量为2000的聚乙二醇（PEG），并且通过l -赖氨酸残基在树状分子的每个链端都含有甲基丙烯酰基。通过(1)H核磁共振（NMR）判断，在自由基引发剂（偶氮二异丁腈和过氧化二苯甲酰）的作用下，枝状大分子的甲基丙烯酰基被成功聚合。GPC结果表明，具有可聚合基团的枝状大分子在聚合后分子量没有变化，表明甲基丙烯酰基的聚合发生在单个枝状大分子内。聚合甲基丙烯基导致树状大分子对客体分子的亲和力显著降低，这表明由甲基丙烯基连接形成的外围网络隐藏了树状大分子的内部。此外，当树状大分子的甲基丙烯酰基在玫瑰红的存在下聚合时，客体分子被发现与树状大分子紧密结合。(C) 2005 Elsevier Ltd版权所有。
Toward the production of unimolecular nanocapsules with biocompatible surface, we prepared a fourth generation polyamidoamine dendrimer having both a poly(ethylene glycol) (PEG) with the number average molecular weight of 2000 and a methacryloyl group at every chain end of the dendrimer through an L-lysine residue. The introduced methacryloyl groups of the dendrimer were successfully polymerized by using free radical initiators, such as azobisisobutyronitrile and dibenzoyl peroxide, as judged by (1)H NMR. GPC revealed that the molecular weight of the dendrimers having the polymerizable groups did not change after their polymerization, indicating that the polymerization of the methacryloyl groups took place within the single dendrimer. Polymerization of the methacryloyl groups resulted in a significant reduction of the affinity of the dendrimer to a guest molecule, rose bengal, suggesting that the peripheral network formed by the linking of methacryloyl groups hides the dendrimer interior. In addition, when the methacryloyl groups of the dendrimer were polymerized in the presence of rose bengal, the guest molecule was found to be tightly associated with the dendrimer. (C) 2005 Elsevier Ltd. All rights reserved.