Maintained exercise-enhanced brain executive function related to cerebral lactate metabolism in men
Maintained exercise-enhanced brain executive function related to cerebral lactate metabolism in men
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DOI：
10.1096/fj.201700381rr
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发表时间：
2018-03-01
期刊：
影响因子：
4.8
通讯作者：
Ogoh, Shigehiko
中科院分区：
文献类型：
--
作者：
Hashimoto, Takeshi;Tsukamoto, Hayato;Ogoh, Shigehiko
高强度间歇运动（HIIE）可改善大脑执行功能（EF），但重复HIIE后EF的改善减弱，可能是因为大脑的乳酸可用性较低。本研究探讨了运动后EF的改善是否与脑乳酸摄取有关。14名健康的男性受试者进行2个HIIE方案，间隔60分钟休息。从右颈内静脉球和肱动脉获得血液样品，以确定跨脑的乳酸（a-v diff（乳酸））、葡萄糖（a-v diff（葡萄糖））、氧（a-v diff（氧））和脑源性神经营养因子（BDNF; a-v diff（BDNF））的动脉-静脉差异。EF采用色词Stroop任务进行评价。第一次HIIE改善EF 40分钟，而第二次HIIE仅在运动后立即改善EF。与第一次HIIE相比，第二次HIIE后a-v diff（葡萄糖）无变化，而a-v diff（BDNF）增加相似，a-v diff（乳酸）增加，但增加减弱（P < 0.05）。HIIE后EF与a-v diff（lactate）相关（r（2）= 0.62; P < 0.01）。我们认为，反复HIIE后EF的衰减改善与脑乳酸代谢降低有关，因此，与全身代谢有关，是乳酸穿梭机制的一个例子。
High-intensity interval exercise (HIIE) improves cerebral executive function (EF), but the improvement in EF is attenuated after repeated HIIE, perhaps because of lower lactate availability for the brain. This investigation examined whether improved EF after exercise relates to brain lactate uptake. Fourteen healthy, male subjects performed 2 HIIE protocols separated by 60 min of rest. Blood samples were obtained from the right internal jugular venous bulb and from the brachial artery to determine arterial-venous differences across the brain for lactate (a-v diff(lactate)), glucose (a-v diff(glucose)), oxygen (a-v diff(oxygen)), and brain-derived neurotrophic factor (BDNF; a-v diff(BDNF)). EF was evaluated by the color-word Stroop task. The first HIIE improved EF for 40 min, whereas the second HIIE improved EF only immediately after exercise. The a-v diff(glucose) was unchanged, whereas the a-v diff(BDNF) increased similarly after both HIIEs, and the a-v diff(lactate) increased, but the increase was attenuated after the second HIIE, compared with the first HIIE (P < 0.05). The EF after HIIE correlated with the a-v diff(lactate) (r(2) = 0.62; P < 0.01). We propose that attenuated improvement in EF after repeated HIIE relates to reduced cerebral lactate metabolism and is, thereby, linked to systemic metabolism as an example of the lactate shuttle mechanism.