The pattern-pulse multifocal visual evoked potential
The pattern-pulse multifocal visual evoked potential
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DOI：
10.1167/iovs.02-0608
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发表时间：
2003-02-01
影响因子：
4.4
通讯作者：
James, AC
中科院分区：
文献类型：
--
作者：
James, AC
目的。定义模式脉冲多焦视觉诱发电位（PPMVEP），并确定其在正常受试者样本中的特征，包括可达到的反应幅度、跨视野的波形变化和头皮电位分布，并将模式脉冲与对比反转多焦刺激进行比较。vep是通过同时用模式对比脉冲刺激60个皮层缩放的飞镖靶区域获得的。采用32通道脑电图记录系统记录正常人的反应，并对刺激信号进行各反应通道信号的多元回归估计各区域的初等反应。通过双视刺激同时测试左眼、右眼和双眼的观看情况。然后用对比逆转刺激进行直接比较。12个受试者的响应波形集的最大振幅在1.8到6.8 μ v之间变化。在大多数实验对象中存在的一种典型的波形分布，主要取决于刺激物在视野中的极角位置。在与对比反转多焦点分析的直接比较中，模式脉冲响应具有相似的波形和头皮地形，但振幅大15倍。模式脉冲刺激组的根均方（RMS）信噪比（SNR）提高了1.9倍，相当于在达到相同信噪比的情况下减少了73%的记录时间。PPMVEP可以在不到7分钟的时间内同时描绘两只眼睛视野的60个区域。一个一般的方法是说明，允许多焦点分析与灵活选择的刺激条件。
PURPOSE. To define the pattern-pulse multifocal visual evoked potential (PPMVEP) and determine its characteristics in a sample of normal subjects in terms of amplitude of response attainable, the variation in waveform across visual field, and distribution of potential over the scalp and to compare pattern-pulse with contrast-reversal multifocal stimuli.METHODS. VEPs were obtained by concurrently stimulating 60 regions of a cortically scaled dartboard with pulses of pattern contrast. Responses were recorded from normal subjects, by using a 32-channel electroencephalogram recording system, and elementary responses to each region were estimated by multiple regression of each of the response channel signals on stimulus signals. Left-eye, right-eye, and binocular viewing conditions were concurrently tested by dichoptic stimulation. A direct comparison was then made with contrast-reversal stimulation.RESULTS. Response waveform sets for 12 subjects varied in maximum amplitude from 1.8 to 6.8 muV. A stereotypical distribution of waveforms held in most subjects, depending primarily on the polar angle location of the stimulus within the visual field. In a direct comparison with a contrast-reversal multifocal analysis, the pattern-pulse responses had similar waveforms and scalp topography, but were 15 times larger in amplitude. Root mean square (RMS) signal-to-noise ratio (SNR) was 1.9 times higher with pattern-pulse stimulation, corresponding to a reduction of 73% in recording time to achieve the same SNR.CONCLUSIONS. The PPMVEP can simultaneously characterize 60 regions of the visual field for both eyes in less than 7 minutes. A general methodology is illustrated that allows multifocal analysis with flexible choice of stimulus conditions.