Dissociating the role of endocannabinoids in the pleasurable and motivational properties of social play behaviour in rats
Dissociating the role of endocannabinoids in the pleasurable and motivational properties of social play behaviour in rats
复制标题
DOI：
10.1016/j.phrs.2016.04.031
复制
发表时间：
2016-08-01
影响因子：
9.3
通讯作者：
Vanderschuren, Louk J. M. J.
中科院分区：
文献类型：
--
作者：
Achterberg, E. J. Marijke;van Swieten, Maaike M. H.;Vanderschuren, Louk J. M. J.
社交游戏行为是一种充满活力的社会互动形式，在许多哺乳动物物种（包括人类）的青少年时期都很常见。社交游戏是非常有益的，对社交和认知发展很重要。作为一种有益的活动，社交游戏可以分为愉悦和动机两部分。我们之前已经证明内源性大麻素可以调节大鼠的社交游戏行为的表达。在本研究中，我们研究了内源性大麻素是否调节社交游戏行为的动机性和愉悦性，分别使用操作性和场所条件反射范式。anandamide水解抑制剂URB597在0.1 mg/kg剂量下不会影响操作性反应或社交游戏诱导的条件位置偏好（CPP），而在0.2 mg/kg剂量下会适度降低操作性反应。当大麻素-1 （CB1）受体拮抗剂利莫那班以已知减少社交游戏行为表达的剂量（1mg /kg）给药时，降低了操作反应，尽管这种作用可能次于当前药物诱导的刻板行为（即梳理和抓挠）。这些数据表明，提高内源性大麻素水平不会对社交游戏行为的动机和愉悦方面产生不同的影响，而CB1受体阻断则会降低社交游戏行为的动机方面，这可能是由于反应竞争。因此，内源性大麻素可能会驱动社交游戏行为的整体表达，而不会对其动机或愉悦特性产生不同的影响。(C) 2016 Elsevier Ltd.版权所有。
Social play behaviour is a vigorous form of social interaction, abundant during the juvenile and adolescent phases of life in many mammalian species, including humans. Social play is highly rewarding and it is important for social and cognitive development. Being a rewarding activity, social play can be dissociated in its pleasurable and motivational components. We have previously shown that endocannabinoids modulate the expression of social play behaviour in rats. In the present study, we investigated whether endocannabinoids modulate the motivational and pleasurable properties of social play behaviour, using operant and place conditioning paradigms, respectively. Treatment with the anandamide hydrolysis inhibitor URB597 did not affect operant responding or social play-induced conditioned place preference (CPP) when administered at a dose (0.1 mg/kg) known to increase the expression of social play behaviour, while it modestly reduced operant responding at a higher dose (0.2 mg/kg). The cannabinoid-1 (CB1) receptor antagonist rimonabant reduced operant responding when administered at a dose (1 mg/kg) known to decrease the expression of social play behaviour, although this effect may be secondary to don current drug-induced stereotypic behaviours (i.e., grooming and scratching). These data demonstrate that enhancing endocannabinoid levels does not differentially affect the motivational and pleasurable aspects of social play behaviour, whereas CB1 receptor blockade reduces the motivational aspects of social play behaviour, possibly due to response competition. Thus, endocannabinoids likely drive the expression of social play behaviour as a whole, without differentially affecting its motivational or pleasurable properties. (C) 2016 Elsevier Ltd. All rights reserved.