An innovative electrochemical platform for the sensitive determination of the hepatitis B inhibitor Entecavir with ionic liquid as a mediator
An innovative electrochemical platform for the sensitive determination of the hepatitis B inhibitor Entecavir with ionic liquid as a mediator
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DOI：
10.1016/j.molliq.2020.112498
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发表时间：
2020-03-15
影响因子：
6
通讯作者：
Allam, Nageh K.
中科院分区：
文献类型：
--
作者：
Asran, Aml M.;Mohamed, Mona A.;Allam, Nageh K.
我们报告了一种简便的方法来制造纳米颗粒修饰的碳糊电极，对恩替卡韦（ENT）的电化学测定具有高灵敏度和反应性，允许最佳的电荷转移/电极动力学。离子液体的使用提供了更宽的电化学窗口，有利于ENT的有效测定。电化学平台基于NiFe 2 O 4纳米颗粒与室温离子液体混合制成碳糊电极（NiFe 2 O 4-IL/CPE）。合成的复合材料的特点是使用不同的技术。值得注意的是，NiFe 2 O 4纳米颗粒的物理性质，如形状、尺寸、结构、面积和孔隙率，控制着传感器表面的电化学过程。在pH2.0时，方波伏安法（SWV）对ENT的检测具有两个较宽的线性动态范围：0.80 × 10（-8）-2.20 × 10（-6）mol L-1和2.20 × 10（-6）-1.55 × 10（-4）mol L-1。NiFe_2 O_4-IL/CPE传感器用于尿液、血浆和药品中ENT的分析。制备的NiFe 2 O 4-IL/CPE具有潜在的用于临床检测和药品质量保证。(C)2020爱思唯尔B. V.保留所有权利。
We report on a facile method to fabricate nanoparticles-modified carbon paste electrodes with high sensitivity and reactivity towards the electrochemical determination of Entecavir (ENT), allowing for optimal charge transfer/electrode kinetics. The use of ionic liquid provides wider electrochemical window that facilitates the effective determination of ENT. The electrochemical platform is based on mixing NiFe2O4 nanoparticles with room temperature ionic liquids into carbon paste electrode (NiFe2O4-IL/CPE). The synthesized composite is characterized using different techniques. Outstandingly, the physical properties of the NiFe2O4 nanoparticles, regarding the shape, size, structure, area, and porosity control the electrochemical processes at the surface of the sensor. The sensing of ENT via square wave voltammetry (SWV) is found to exhibit two wide linear dynamic ranges of 0.80 x 10(-8)-2.20 x 10(-6) mol L-1 and 2.20 x 10(-6)-1.55 x 10(-4) mol L-1 at pH 2.0. The NiFe2O4-IL/CPE sensor is explored towards the analysis of ENT in urine, plasma and pharmaceutical products. The fabricated NiFe2O4-IL/CPE has the potential to be used as a clinical assay and QA in pharmaceutical products. (C) 2020 Elsevier B.V. All rights reserved.