Extent of spontaneous motor recovery after traumatic cervical sensorimotor complete spinal cord injury
Extent of spontaneous motor recovery after traumatic cervical sensorimotor complete spinal cord injury
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DOI：
10.1038/sc.2010.99
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发表时间：
2011-02-01
期刊：
影响因子：
2.2
通讯作者：
Curt, A.
中科院分区：
文献类型：
--
作者：
Steeves, J. D.;Kramer, J. K.;Curt, A.
研究设计：根据国际脊髓损伤神经学分类标准（ISNCSCI），对颈椎（C4-C7）感觉运动完全性脊髓损伤（SCI）患者的运动恢复数据进行回顾性纵向分析。目的：分析创伤性颈椎感觉运动完全性脊髓损伤后第一年内自发运动恢复的程度和模式。方法：对来自欧洲多中心SCI研究（EMSCI）和Sygen随机临床试验的数据集进行了检查，以了解美国脊髓损伤协会（ASIA）损伤量表（AIS）等级的转换、上肢运动评分（UEMS）或运动水平的变化以及这些指标之间的关系。在运动恢复模式方面，EMSCI和Sygen数据集之间没有总体差异。1年后，高达70%的受试者自发恢复了至少一个运动水平，但只有30%的受试者恢复了两个或更多个运动水平，中间时间点的数值较小。AIS等级转换对运动水平变化无显著影响。1年时，双侧UEMS的平均自发改善为10-11个运动点。UEMS的变化与颈椎运动水平的变化之间仅存在中度相关性（r（2）=0.30，P
Study design: Retrospective, longitudinal analysis of motor recovery data from individuals with cervical (C4-C7) sensorimotor complete spinal cord injury (SCI) according to the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI).Objectives: To analyze the extent and patterns of spontaneous motor recovery over the first year after traumatic cervical sensorimotor complete SCI.Methods: Datasets from the European multicenter study about SCI (EMSCI) and the Sygen randomized clinical trial were examined for conversion of American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade, change in upper extremity motor score (UEMS) or motor level, as well as relationships between these measures.Results: There were no overall differences between the EMSCI and Sygen datasets in motor recovery patterns. After 1 year, up to 70% of subjects spontaneously recovered at least one motor level, but only 30% recovered two or more motor levels, with lesser values at intermediate time points. AIS grade conversion did not significantly influence motor level changes. At 1 year, the average spontaneous improvement in bilateral UEMS was 10-11 motor points. There was only moderate relationship between a change in UEMS and a change in cervical motor level (r(2)=0.30, P