Quantitative 99mTc-DPD SPECT/CT in patients with suspected ATTR cardiac amyloidosis: Feasibility and correlation with visual scores
Quantitative 99mTc-DPD SPECT/CT in patients with suspected ATTR cardiac amyloidosis: Feasibility and correlation with visual scores
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DOI：
10.1007/s12350-019-01893-8
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发表时间：
2020-10-01
影响因子：
2.4
通讯作者：
Zellweger, Michael J.
中科院分区：
文献类型：
--
作者：
Caobelli, Federico;Braun, Martin;Zellweger, Michael J.
目的虽然通过Perugini评分对Tc-99 m-DPD闪烁成像进行目视解读可以提供甲状腺素运载蛋白相关（ATTR）心脏淀粉样变性（CA）的可靠诊断，但预计定量方法将在风险分层和治疗中发挥重要作用评估。我们研究的目的是测试定量评估的可行性，并将各种参数与Perhapi评分相关联。方法回顾性研究中，连续患者接受了Tc-99 m-DPD全身骨显像和胸部SPECT/CT检查。使用XSPECT-QUANT软件定量心脏中的DPD摄取。结果13例患者入选。CA在8例中得到确认，在5例中被拒绝。心肌SUVmax和SUVpeak与Percusi评分显示出相当强的相关性（rho = 0.71，P = 0.006）。对于骨标准化值也是如此（rho = 0.75，P = 0.003）。Percusi评分为2和3的患者的定量值有很大程度的重叠。结论定量Tc-DPD SPECT/CT对可疑ATTR CA患者心肌摄取的评价是可行的。
Purpose While a visual interpretation of Tc-99m-DPD scintigraphy by means of Perugini score can provide a reliable diagnosis of transthyretin-related (ATTR) cardiac amyloidosis (CA), a quantitative approach is expected to play a major role in risk stratification and therapy evaluation. The aim of our study was to test the feasibility of a quantitative assessment and to correlate various parameters to Perugini score. Methods in this retrospective study, consecutive patients underwent a Tc-99m-DPD whole-body bone scintigraphy and a SPECT/CT of the thorax. XSPECT-QUANT software was used to quantify the DPD uptake in the heart. Results Thirteen patients were included. CA was confirmed in 8 and rejected in 5. Myocardial SUVmax and SUVpeak showed a fairly strong correlation with Perugini score (both rho = .71, P = .006). Same held true for to-bone normalized values (both rho = .75, P = .003). There was a great degree of overlap for quantitative values in patients with Perugini score 2 and 3. Conclusion Quantitative Tc-99m-DPD SPECT/CT in suspected ATTR CA patients is feasible and allows for a more accurate assessment of myocardial uptake.