'Reinventing the wheel' to advance the development of pain therapeutics.
'Reinventing the wheel' to advance the development of pain therapeutics.
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DOI：
10.1097/fbp.0000000000000596
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发表时间：
2021-04-01
影响因子：
1.6
通讯作者：
Morgan MM
中科院分区：
文献类型：
--
作者：
Kandasamy R;Morgan MM
慢性疼痛影响着全球约三分之一的人口。动物研究的主要目标是了解疼痛背后的神经机制，以便开发更好的治疗方法。尽管在时间和金钱上投入了巨大的资金，但几乎没有开发出治疗疼痛的新方法。造成药物开发中缺乏翻译的因素有很多。动物的药物开发目标(抑制疼痛诱发的反应)和人类的治疗目标(恢复功能)之间的不匹配是一个主要问题。为了解决这个问题，已经开发了一些疼痛抑郁行为测试来评估实验室动物正常行为的变化。使用家庭笼轮跑步作为疼痛评估工具特别有用，因为它易于使用，提供了疼痛程度和持续时间的客观测量，并且是筛选新药的临床相关方法。疼痛会抑制人和动物的活动，有效的止痛治疗会恢复活动。与传统的疼痛诱发测试(如热板、甩尾、von Frey测试)不同，家庭笼轮运行的恢复评估治疗既有抗伤害性效果，又没有破坏性副作用(如镇静、瘫痪、恶心)。本文回顾了使用车轮跑来评估疼痛的文献，并将家庭笼轮跑作为一种有效和临床相关的方法来筛选新型止痛药的治疗潜力。
Chronic pain affects approximately one third of the population worldwide. The primary goal of animal research is to understand the neural mechanisms underlying pain so better treatments can be developed. Despite an enormous investment in time and money, almost no novel treatments for pain have been developed. There are many factors that contribute to this lack of translation in drug development. The mismatch between the goals of drug development in animals (inhibition of pain-evoked responses) and treatment in humans (restoration of function) is a major problem. To solve this problem, a number of pain-depressed behavioral tests have been developed to assess changes in normal behavior in laboratory animals. The use of home cage wheel running as a pain assessment tool is especially useful in that it is easy to use, provides an objective measurement of the magnitude and duration of pain, and is a clinically relevant method to screen novel drugs. Pain depresses activity in humans and animals, and effective analgesic treatments restore activity. Unlike traditional pain-evoked tests (e.g., hot plate, tail flick, von Frey test), restoration of home cage wheel running evaluates treatments for both antinociceptive efficacy and the absence of disruptive side effects (e.g., sedation, paralysis, nausea). This article reviews the literature using wheel running to assess pain and makes the case for home cage wheel running as an effective and clinically relevant method to screen novel analgesics for therapeutic potential.