Noninvasive quantitation of regional myocardial oxygen consumption in vivo with [1-11C]acetate and dynamic positron emission tomography.
Noninvasive quantitation of regional myocardial oxygen consumption in vivo with [1-11C]acetate and dynamic positron emission tomography.
复制标题
使用[1-11C]乙酸盐和动态正电子发射断层扫描对体内局部心肌耗氧量进行无创定量。
DOI：
10.1161/01.cir.79.1.134
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发表时间：
1989
期刊：
影响因子：
37.8
通讯作者：
Schelbert,HR
中科院分区：
文献类型：
--
作者：
Buxton,DB;Nienaber,CA;Luxen,A;Ratib,O;Hansen,H;Phelps,ME;Schelbert,HR
[1-11C]乙酸盐作为正电子发射断层扫描中整体心肌氧化代谢示踪剂的有用性已在 12 只闭胸犬中进行了研究。通过正电子发射断层扫描无创地测定了狗静脉注射[1-11C]乙酸后的心肌11C活性清除动力学。对局部心肌 11C 时间-活性曲线进行双指数拟合，得出清除半衰期和分数分布。 11C 活性清除早期快速相的速率常数 k1 与心肌耗氧量线性相关 (y = 0.0156x + 0.039; SEE = 0.023; r = 0.95)。与左心室游离壁相比，间隔部分的 k1 大约低 7%，表明间隔区域的耗氧量较低；还观察到隔膜中相对于左心室游离壁的血流伴随的局部衰减。以碳水化合物为主要燃料的狗，k1 耗氧量略高于以游离脂肪酸为主的狗（0.021 +/- 0.002 与 0.018 +/- 0.002 相比，p 小于 0.01），表明在恒定耗氧量下，碳水化合物消耗的增加与 k1 的小幅增加有关。结论是，心肌[1-11C]乙酸动力学的测量允许通过正电子发射断层扫描无创地确定心脏耗氧量，并且该技术对心肌燃料选择相对不敏感。
The usefulness of [1-11C]acetate as a tracer of overall myocardial oxidative metabolism for use with positron emission tomography has been investigated in 12 closed-chest dogs. Myocardial 11C activity clearance kinetics after intravenous administration of [1-11C]acetate in dogs have been determined noninvasively by positron emission tomography. Biexponential fitting of regional myocardial 11C time-activity curves was performed to give clearance half-times and fractional distribution. The rate constant k1 for the early rapid phase of 11C activity clearance was found to correlate linearly with myocardial oxygen consumption (y = 0.0156x + 0.039; SEE = 0.023; r = 0.95). k1 was approximately 7% lower in septal sectors compared with the left ventricular free wall, suggesting that regional oxygen consumption in the septum was lower; a concomitant regional attenuation of blood flow in the septum relative to the left ventricular free wall was also observed. In dogs using carbohydrates as the predominant fuel, k1 oxygen consumption was somewhat more than in dogs using predominantly free fatty acids (0.021 +/- 0.002 compared with 0.018 +/- 0.002, p less than 0.01), indicating that increased carbohydrate consumption is associated with a small increase in k1 at constant oxygen consumption. It is concluded that measurement of myocardial [1-11C]acetate kinetics allows noninvasive determination of cardiac oxygen consumption by positron emission tomography and that the technique is relatively insensitive to myocardial fuel selection.