Complex Highways on the Translational Roadmap for Therapeutic Ultrasound-Targeted Microbubble Cavitation: Where Are We Now?
Complex Highways on the Translational Roadmap for Therapeutic Ultrasound-Targeted Microbubble Cavitation: Where Are We Now?
复制标题
超声靶向微泡空化治疗转化路线图上的复杂高速公路：我们现在在哪里？
DOI：
10.1016/j.jcmg.2019.08.010
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Chen,Xucai
中科院分区：
文献类型：
--
作者：
Villanueva,FlordelizaS;Chen,Xucai
治疗聚焦超声提供了一种非侵入性的方法，有针对性地将消融声能输送到身体内的结构。高强度聚焦超声是治疗性超声的一种形式，其利用聚焦声能转化为热能来损伤靶组织，例如目前用于癌症（1）和原发性震颤（2）。最近已经结合诊断超声造影剂探索了利用超声的生物效应用于治疗目的，所述诊断超声造影剂包括充气壳封装的微球（微泡）。这些微泡中的几种被美国食品和药物管理局批准在超声心动图、肝脏成像和膀胱输尿管反流的评价中用作左心室腔混浊的红细胞示踪剂（3）。微泡响应于超声的循环而压缩和膨胀（振荡或空化）。在这样做时，微泡将超声波的能量（毫米量级的波长）聚焦到微米量级的空间，导致高度局部化的（通常是高的）剪切应力和/或通过惯性空化的微泡破坏。
Therapeutic focused ultrasound offers a noninvasive approach to targeted delivery of ablative acoustic energy to structures within the body. High-intensity focused ultrasound is one form of therapeutic ultrasound that capitalizes on the conversion of focused acoustic energy into thermal energy to injure target tissues, such as currently used for cancer (1) and essential tremor (2). Harnessing the bioeffects of ultrasound for therapeutic purposes has more recently been explored in conjunction with diagnostic ultrasound contrast agents, which comprise gas-filled shell-encapsulated microspheres (microbubbles). Several of these microbubbles are approved by the Food and Drug Administration for use as red cell tracers for left ventricular cavity opacification during echocardiography, liver imaging, and evaluation of vesicoureteral reflux (3). Microbubbles compress and expand (oscillate or cavitate) in response to the cycles of ultrasound. In so doing, the microbubbles focus the energy of the ultrasound wave (wavelength on the order of millimeters) to a space on the order of magnitude of microns, leading to highly localized, often high, shear stress and/or microbubble destruction through inertial cavitation.